ID A2ALD2_MOUSE Unreviewed; 312 AA.
AC A2ALD2; E9PXR8;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 15-FEB-2017, sequence version 2.
DT 27-MAR-2024, entry version 140.
DE RecName: Full=Olfactory receptor {ECO:0000256|RuleBase:RU363047};
GN Name=Or9g4 {ECO:0000313|Ensembl:ENSMUSP00000097501.3,
GN ECO:0000313|MGI:MGI:3030840};
GN Synonyms=Olfr1006 {ECO:0000313|MGI:MGI:3030840};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000097501.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000097501.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097501.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000097501.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000097501.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363047};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363047}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR RefSeq; NP_666781.2; NM_146570.2.
DR STRING; 10090.ENSMUSP00000149868; -.
DR PaxDb; 10090-ENSMUSP00000097501; -.
DR Antibodypedia; 58999; 101 antibodies from 22 providers.
DR DNASU; 258563; -.
DR Ensembl; ENSMUST00000099917.4; ENSMUSP00000097501.3; ENSMUSG00000075211.5.
DR Ensembl; ENSMUST00000216084.2; ENSMUSP00000149868.2; ENSMUSG00000075211.5.
DR GeneID; 258563; -.
DR KEGG; mmu:258563; -.
DR UCSC; uc008kkp.1; mouse.
DR AGR; MGI:3030840; -.
DR CTD; 283189; -.
DR MGI; MGI:3030840; Or9g4.
DR VEuPathDB; HostDB:ENSMUSG00000075211; -.
DR eggNOG; ENOG502SIHB; Eukaryota.
DR GeneTree; ENSGT01100000263494; -.
DR OMA; PQWQPIL; -.
DR OrthoDB; 4657152at2759; -.
DR TreeFam; TF352735; -.
DR BioGRID-ORCS; 258563; 2 hits in 71 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 2.
DR GO; GO:0016020; C:membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR CDD; cd15418; 7tmA_OR9G-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR48018; OLFACTORY RECEPTOR; 1.
DR PANTHER; PTHR48018:SF129; OLFACTORY RECEPTOR 9G4; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU363047};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Olfaction {ECO:0000256|ARBA:ARBA00022725, ECO:0000256|RuleBase:RU363047};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU363047};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 41..290
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 312 AA; 34890 MW; B505F1212FB0DE3F CRC64;
MELDNRTILT EFILVGFSAD PHWQLTLFGI FLTIYLLTLS GNMLLVVLIR IDSRLHTPMY
FFISNLSFLD FWYTSVYTPK ILATCISEDK RISLAGCGAQ LFFSCVVAYT ECYLLAAMAY
DRHSAICSPL IYSSIMSSSL CTGLVAGCYI GGVLNAIAHT ANTFRLTFCG KNIIDHFFCD
APPLVKMSCT DTRVYEKVLL GVVGFTVLSS ILAILISYFN ILLAILRIRS ASGRRKAFST
CASHLVSVML FYGSLLFMYS RPSSTYSLEK DKVAALFYTV VNPLLNPLIY SLRNKDVKDA
FRKATQTIRP HT
//
