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Database: UniProt
Entry: A2ALL3_MOUSE
LinkDB: A2ALL3_MOUSE
Original site: A2ALL3_MOUSE 
ID   A2ALL3_MOUSE            Unreviewed;       280 AA.
AC   A2ALL3;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   11-DEC-2019, entry version 96.
DE   SubName: Full=E3 ubiquitin-protein ligase RNF186 {ECO:0000313|Ensembl:ENSMUSP00000111780};
GN   Name=Rnf186 {ECO:0000313|Ensembl:ENSMUSP00000111780,
GN   ECO:0000313|MGI:MGI:1914075};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000111780, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000111780, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000111780,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000111780}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000111780};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AL805923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_080062.4; NM_025786.3.
DR   PRIDE; A2ALL3; -.
DR   Ensembl; ENSMUST00000116094; ENSMUSP00000111780; ENSMUSG00000070661.
DR   GeneID; 66825; -.
DR   KEGG; mmu:66825; -.
DR   UCSC; uc008vlo.2; mouse.
DR   CTD; 54546; -.
DR   MGI; MGI:1914075; Rnf186.
DR   eggNOG; KOG2177; Eukaryota.
DR   eggNOG; ENOG4111G04; LUCA.
DR   GeneTree; ENSGT00510000049175; -.
DR   HOGENOM; HOG000231633; -.
DR   OMA; KLLGCQH; -.
DR   OrthoDB; 1446732at2759; -.
DR   PhylomeDB; A2ALL3; -.
DR   TreeFam; TF331690; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000070661; Expressed in 77 organ(s), highest expression level in colon.
DR   Genevisible; A2ALL3; MM.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR   GO; GO:0035519; P:protein K29-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR   GO; GO:0070585; P:protein localization to mitochondrion; IEA:Ensembl.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR038878; RNF186.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR22791:SF12; PTHR22791:SF12; 1.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   TRANSMEM        208..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        233..251
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          93..139
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  30223 MW;  E85A915DF850DA28 CRC64;
     MPDIGCQQVP AESRRETGSV PTGPEPMQVL AAPVDVACGC PCADQPCPST SVPRMSCTEA
     PQPIPAGTTT TSTIIALGPT GRLSISVEGD LECLVCREPY NCARSPKLLS CQHTFCAVCL
     KLLLYVQEDT WSIPCPLCRK VTAVPGGLIC SLRDQEAMVG RLALPCPEVR LCPQRLVGSA
     ASATRPANWT GEEEQDTVSV NRVAARRLAV HLLLLALVIV LILPFIYPGV IRWVLAFVIA
     LALLMSTLFC CHPQSQNSNW LCPRTLFCRE QKQTQITSIA
//
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