ID A2AR76_MOUSE Unreviewed; 447 AA.
AC A2AR76;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=TRAF family member-associated Nf-kappa B activator {ECO:0000313|Ensembl:ENSMUSP00000108121.2};
GN Name=Tank {ECO:0000313|Ensembl:ENSMUSP00000108121.2,
GN ECO:0000313|MGI:MGI:107676};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000108121.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000108121.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108121.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000108121.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000108121.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_006499150.1; XM_006499087.2.
DR AlphaFoldDB; A2AR76; -.
DR SMR; A2AR76; -.
DR jPOST; A2AR76; -.
DR MaxQB; A2AR76; -.
DR PeptideAtlas; A2AR76; -.
DR ProteomicsDB; 303941; -.
DR Antibodypedia; 4155; 501 antibodies from 38 providers.
DR DNASU; 21353; -.
DR Ensembl; ENSMUST00000112502.8; ENSMUSP00000108121.2; ENSMUSG00000064289.16.
DR AGR; MGI:107676; -.
DR MGI; MGI:107676; Tank.
DR VEuPathDB; HostDB:ENSMUSG00000064289; -.
DR GeneTree; ENSGT00390000008712; -.
DR OrthoDB; 5358337at2759; -.
DR BioGRID-ORCS; 21353; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Tank; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000064289; Expressed in granulocyte and 261 other cell types or tissues.
DR ExpressionAtlas; A2AR76; baseline and differential.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:InterPro.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR039669; TANK.
DR InterPro; IPR024581; TBD.
DR PANTHER; PTHR15249; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR PANTHER; PTHR15249:SF0; TRAF FAMILY MEMBER-ASSOCIATED NF-KAPPA-B ACTIVATOR; 1.
DR Pfam; PF12845; TBD; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:A2AR76,
KW ECO:0007829|MaxQB:A2AR76};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 415..442
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT COILED 61..95
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 447 AA; 50811 MW; F42722A3472BF923 CRC64;
MSLKRHSLRR NACHLETRAG IPTILYSDAT GQRGMDKNIG EQLNRAYEAF RQACMDRDSA
VRELQQKTEN YEQRIREQQE QLSFQQNLID RLKSQLLLVD SSRDNSYGYV PLLEDSDRRK
NNLTLDEPHD KVKLGTLRDK QSKVRRQEVS SGKESAKGLN IPLHHERDNI EKTFWDLKEE
FHRICLLAKA QKDHLSKLNI PDIATDTQCS VPIQCTDKTE KQEALFKPQA KDDINRGMSC
VTAVTPRGLG RDEEDTSFES LSKFNVKFPP MDNDSIFLHS TPEAPSILAP ATPETVCQDR
FNMEVRDNPG NFVKTEETLF EIQGIDPITS AIQNLKTTDK TNPSNLRATC LPAGDHNVFY
VNTFPLQDPP DAPFPSLDSP GKAVRGPQQP FWKPFLNQDT DLVVPSDSDS ELLKPLVCEF
CQELFPPSIT SRGDFLRHLN THFNGET
//
