ID A2AS05_MOUSE Unreviewed; 2903 AA.
AC A2AS05;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 08-APR-2008, sequence version 2.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Helicase with zinc finger 2, transcriptional coactivator {ECO:0000313|Ensembl:ENSMUSP00000112917.2};
GN Name=Helz2 {ECO:0000313|Ensembl:ENSMUSP00000112917.2,
GN ECO:0000313|MGI:MGI:2385169};
GN Synonyms=BC006779 {ECO:0000313|MGI:MGI:2385169};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000112917.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000112917.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112917.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000112917.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112917.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR SMR; A2AS05; -.
DR MaxQB; A2AS05; -.
DR PeptideAtlas; A2AS05; -.
DR ProteomicsDB; 357697; -.
DR Antibodypedia; 63897; 51 antibodies from 17 providers.
DR Ensembl; ENSMUST00000121484.2; ENSMUSP00000112917.2; ENSMUSG00000027580.18.
DR AGR; MGI:2385169; -.
DR MGI; MGI:2385169; Helz2.
DR VEuPathDB; HostDB:ENSMUSG00000027580; -.
DR GeneTree; ENSGT00940000160694; -.
DR HOGENOM; CLU_000407_0_0_1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000027580; Expressed in lymph node and 184 other cell types or tissues.
DR ExpressionAtlas; A2AS05; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd18808; SF1_C_Upf1; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR047187; SF1_C_Upf1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR Pfam; PF13086; AAA_11; 3.
DR Pfam; PF13087; AAA_12; 2.
DR Pfam; PF00773; RNB; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|EPD:A2AS05,
KW ECO:0007829|MaxQB:A2AS05};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 1567..1924
FT /note="Ribonuclease II/R"
FT /evidence="ECO:0000259|SMART:SM00955"
FT REGION 1260..1292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2903 AA; 326591 MW; 88D3F52EC359BCFD CRC64;
MASVGCSLRS ASTSATNGPS LAGLCAKVDL YLGCSRCTQC LNESTYILRE VEHTCPREIL
LARFKQAAES KIWRKVGRRP SFPTPMRYQV CHYYRPGLGC RRHWNRCTFA RSPEEALVWT
FELKNNLPRL KLKEAVQGTR APDRLQTPAD TIRAEFGGHF QLLCAICFTC CPPCLCPVDP
RGHCPKHQIC PTLLIHVIVE GLKRQFVEVR PLPQRRHPLN YCMYVGRGVP CRHGASRCEY
AHSAVEMAVW KAEQLDGLQR GDLLTYPLFG ENKWKASPNP NPPVTKLYCH ACLVTCNSQE
AFENHCSSLE HAQMVAFDQA VPWKHRAPPM GLSKFDLCPR PDLCEHGEVC IKAHSKQELQ
EWVQRAQDME LREQAAWQDG LVPYQARLLA EYQRSSKEVS VMAETIRGVS VTCHPPPVHQ
AQEKIQHQWV FTIHSEDPLL HVALLNQEPG AAFSLVAPSL PPHQLYAQGK HFCVQSSPAQ
YKVGVLVQAV AFGSFEQWVV FDFGRRPVLL QKLKLQLGQT HSQGLNGKPA PSHPQELECW
HTGNRHVVLE VDWTPEQEAL MAKYKLPSLA LEFNQIVPDW GPISRSNYRQ RMHKFLYEEE
AAQQQLVAKL AMKGQVSLKT ALETPALGML FAPPGALYAK VPFHSSLLPD TDQGFLLSRA
VSTALVAPVP APNSTVYQVR LEARASSDHA LWLLLPARCC MALGLQAQDS PILEVQFQID
PMTFRFWHQA VDALLEEHLV VPDLPACTLP HPWPTPPSFR GNHKQKLAVG LIAGRRPEGT
KHIPPLLIYG PFGTGKTYTL AMAALEVVQQ PHTKVLICTH TNSAADIYIR EYFHDYVSSG
HPEATPLRVM YADRPPRQTD PTTLQYCCLT EDRQAFRPPT GPELVHHRLV VTTTSQAREL
QVPAGFFSHI FIDEAAQMLE CEALIPLSYA LSLTRVVLAG DHMQVTPRLF SVPRDKSARH
TLLHRLFLYY QQEAHKIAQQ SRIIFHENYR STAAIINFVS HHFYLAKGNP IQASGKVPRH
PQHYPLMFCH VAGSPEQDMS MTSWLNSAEV TQVVEKVREI YNTWPHCWGP REQRHICAVS
HGAQVSALRQ ELRRRNLGEV SVGSFEILPG REFRVVVLSS VHNRNSLLSP GAPTSEFFTE
PRVLNTVMTR AQSQLVAVGD AVALCSSGAC RNLWRSFIRE CIEHHSAFPE ELSLEQIEQG
VAQRQNWASL TLKARGPETE QKSMAQGPQR LIAEGTMVTV KAETRAEAAA KAQTAAVAAE
DTASGNSASR DAAAEVSTLE GGMSEEDSES DFWPSDWELN ADDAILKELL DESQQVTVTV
REDGLLDTVV CSAPQKAREY TNLPSSVLWK FLRSNSKQFR RCSFLQETFE RALATPLDDM
ASSPIQVRGR LNCGMAFTGD EVLVQILGPA GDDRCVPGSL QGRVMGVLKR RRHELAFVCR
MDEWDPRIMI PINGSVTKIF VAEMKDPQQV PIHRLIQGQV QRVRHETLKP EDRSTRLFWV
RIVLWRERFY YPLGIVLEVL PKAITWEQGL YILDLEHGLK AHTPDPASVS KALQRYRSEL
NTAAGHREDY RHFLTFTVDP QGACNLDDAL SVRDLGPVYE VAVHIADVAS LVPKDGALDV
EARQQGTVFY APNREPVLML PASLCQDALS LLPGQDRLAI SLFLTMEKGG GQIKSLRFAP
SIIRSDRQLS YEEAEELIKR HPGAGLELPA HLDSVEACVV AACYFSWMLR RQRLSAACYY
EPPDEDSVLG FRTAHIMVQE YMIQFNSHVA EFLVSNKHTQ TLTPLRWQPT PSRQQLDSVF
KKYRGLVPLS LHLCHHSNTD YTPNKQLHLL TSLWKQVQLA AGTQDYSQMV DLIAADDMHP
SLAPACLDLR RALGRSVFGR SSQGKQQPAV HHSLQVDWYT WATSPIRRYL DVVLQRLILL
ALGHRGSTYS NRDIDGLCLD FSRQYASAQS YQRRAYSLHL AIQLKSQPQN KLGFVVDVEM
GARCFKVLFP INRETLPDPC PIHYHSLQLA EHPQELVSQT GVRLVWRRRM YSVQASKLPL
PLLGTSLDPH TQTVDAALWM KLLMLLKEQR WPEIAALIQE QDKRFHPREK VKIHQSRCGH
FVEVVYELGS GDTLQVQLGS SLQRGFLAPT LKLWTVVPGF SLCLEHMERP GDCFSSHVHQ
ALQDQYLQVG EYSGAWGPRC ALESLTNAVT ENDSIVLHDV HISWDTSQGQ LQGTFQLEAA
FLQEKCINIH FGCCYLCIRL EGLPLPLDSS LPGPSGLGPF LNIDPNTYTW VAHGLSGDWD
HELAGGDWDQ ENVDDRQEAP KQVYFLIHHM TMEKVPEEVL RPSARFTVEV LSKQLPDLRK
EEAVRQLKTA SPLVISIALG LPIPEIRWPI SGPRRLVSEL RWPIPGPRRP VSEPHRPMSG
PCGPISEPCR SIPEPCRGNW PRQHSFHKGT GKTVVGFHIV YWFHRSNQEQ MPTDSSPSGE
EQLGGPCVLY CGPSNKSVDV LGGLLLRRKT EMKPLRVYGE QAEATEFPLP GVSNRSLFGK
TSQEGRPNQS LRSITLHHRI RQAPNPYAAE IRKFDAQLRE GKIFSKEDLR VYRRVLGKAR
KHELERHSVI LCTCSCAASK SLKILNVRQI LIDEAGMATE PETLIPLVCF SKTVEKVVLL
GDHKQLRPVV KSEQLQSLGM DRSLFERYHR DAIMLDTQYR MHKDICSFPS VEFYGGKLKT
WSDLRRLPSI LGHTGKPSCS VIFGSVQGHE QKLLVSTEDG NENSRANPEE VTQVVRIIKQ
LTLDRTVDPK DIAVLTPYNA QAAAISRGLM QRGVTGVTVT SITKSQGSEW RYVIVSTVRT
CPRSDVDQRP TKSWLKKFLG FVVDPHQVNV AITRAQEALC IIGDHLLLRC CPLWHRLLDF
CEAQHSLVSA EKVRVQRKSA LSS
//
