ID A2AUX8_MOUSE Unreviewed; 423 AA.
AC A2AUX8;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE RecName: Full=WD repeat, SAM and U-box domain-containing protein 1 {ECO:0000256|ARBA:ARBA00020894};
GN Name=Wdsub1 {ECO:0000313|Ensembl:ENSMUSP00000099812.3,
GN ECO:0000313|MGI:MGI:1919387};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000099812.3, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000099812.3, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099812.3,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000099812.3}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000099812.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001153108.1; NM_001159636.1.
DR AlphaFoldDB; A2AUX8; -.
DR SMR; A2AUX8; -.
DR MaxQB; A2AUX8; -.
DR ProteomicsDB; 359235; -.
DR Antibodypedia; 33718; 123 antibodies from 20 providers.
DR Ensembl; ENSMUST00000102751.9; ENSMUSP00000099812.3; ENSMUSG00000026988.16.
DR GeneID; 72137; -.
DR UCSC; uc012bvs.1; mouse.
DR AGR; MGI:1919387; -.
DR CTD; 151525; -.
DR MGI; MGI:1919387; Wdsub1.
DR VEuPathDB; HostDB:ENSMUSG00000026988; -.
DR GeneTree; ENSGT00940000157230; -.
DR OrthoDB; 5489991at2759; -.
DR BioGRID-ORCS; 72137; 1 hit in 78 CRISPR screens.
DR ChiTaRS; Wdsub1; mouse.
DR Proteomes; UP000000589; Chromosome 2.
DR Bgee; ENSMUSG00000026988; Expressed in olfactory epithelium and 230 other cell types or tissues.
DR ExpressionAtlas; A2AUX8; baseline and differential.
DR Genevisible; A2AUX8; MM.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd09505; SAM_WDSUB1; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46573; WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46573:SF1; WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51698; U_BOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A2AUX8,
KW ECO:0007829|ProteomicsDB:A2AUX8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 50..91
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 105..134
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 146..167
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 234..264
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 276..310
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 330..394
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 401..423
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
SQ SEQUENCE 423 AA; 45593 MW; 2C9D4530EF91A079 CRC64;
MVRLIHTLAD HGDDVSCCAF SAALLATCSL DKTIRLYSLS DFAELPYSPL KFHTYAVHCC
CFSPSGHVLA SCSTDGTTVL WSSHSGHTLT VLEQPGGSPV RVCCFSPDSA YLASGAADGS
IALWNAQTYK LYRCGSVKDS SLVACAFSPD GGLFVTGSSG GDLTVWDDRM RCLHSEKAHD
LGITCCSFSS QPLSGGEGLQ SYQLASCGQD CEIKLWAVTI TRVLGFELKY KSTLSGHCAP
VLACAFSHDG KMLASGSVDK SVIIHGIGPQ SVLHTLTQHT RYVTTCAFAP NTLLLATGSM
DKTVNIWQFD LETPCQGSMN DPLKHFTEEW SEEDVSVWLR AQGLEDLVGI FRANNIDGKE
LLHLTKESLA GDLKIESLGL RSKVLRSIEE LRAKMDSLSS GIPDEFICPI TRELMKDPVI
ASG
//
