ID A2BGK1_DANRE Unreviewed; 600 AA.
AC A2BGK1; A0A8M1NJC5;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Rho GTPase-activating protein 25 {ECO:0000313|Ensembl:ENSDARP00000082939, ECO:0000313|RefSeq:NP_001119876.1};
GN Name=arhgap25 {ECO:0000313|Ensembl:ENSDARP00000082939,
GN ECO:0000313|RefSeq:NP_001119876.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060526-210};
GN Synonyms=si:dkey-13n15.4 {ECO:0000313|RefSeq:NP_001119876.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000082939};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000082939, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082939};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000082939}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000082939};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:NP_001119876.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001119876.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [4] {ECO:0000313|RefSeq:NP_001119876.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001119876.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX470224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001119876.1; NM_001126404.1.
DR STRING; 7955.ENSDARP00000082939; -.
DR PaxDb; 7955-ENSDARP00000082939; -.
DR Ensembl; ENSDART00000088506; ENSDARP00000082939; ENSDARG00000061784.
DR Ensembl; ENSDART00000088506.3; ENSDARP00000082939.2; ENSDARG00000061784.4.
DR GeneID; 562468; -.
DR KEGG; dre:562468; -.
DR AGR; ZFIN:ZDB-GENE-060526-210; -.
DR CTD; 9938; -.
DR ZFIN; ZDB-GENE-060526-210; arhgap25.
DR eggNOG; KOG4270; Eukaryota.
DR HOGENOM; CLU_020795_1_0_1; -.
DR OMA; MIKQHET; -.
DR OrthoDB; 48967at2759; -.
DR PhylomeDB; A2BGK1; -.
DR TreeFam; TF323577; -.
DR Reactome; R-DRE-9013149; RAC1 GTPase cycle.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000061784; Expressed in granulocyte and 13 other cell types or tissues.
DR GO; GO:0001891; C:phagocytic cup; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0006911; P:phagocytosis, engulfment; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd13263; PH_RhoGap25-like; 1.
DR CDD; cd04390; RhoGAP_ARHGAP22_24_25; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF20; RHO GTPASE-ACTIVATING PROTEIN 25; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 3..105
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 114..305
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 306..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 600 AA; 68024 MW; 3284090D850185B3 CRC64;
MEKPLKTGWL KKQRSIVKNW QLRFFVLRGN SLTYHKDDKE STVQGTIPLF SCQVNELPSN
ADDKFLFEII PAGGSTDRER DAYVLMATSQ SEMEEWVRWI RKAIGSRSNG VFGKSLSDIM
VYERKFGARL VPILVEKCAE FIREHGLVEE GIFRLPGQDN QVKQFREAFD AGERPSFPSD
TDVHTVASLL KLYLRELPEP VVPWTQYQDF LDSTLMLDAT TAAKLEKQIS LLPKVNYNLL
SYICRFLFEV QQNSKVNKMS VENLATVMGV NLFKPQVEDA ISMMKGTPMI QKVMTVMIRH
HELLFPPSKD MKPSPLPSRK NKSKKTSNSF VGWESAECEV SSLSESPEEE EVDTPEEQRK
ELRSSESEST TLSPTEFSVT TDTWPESPRK RTQTLPSLGC PPVARIAREP AWDRWSRFPE
SFNENDEKTL SEDIFKLLDL QKVTLFSEVQ KSENEKEEKG QKDKDNTDWS KTDSDVVVQQ
IDAPKAQAQN TAPVPKPQAR IVLSPAASSK ENPAQQTSSA VQPENTDSTS IINSLQQKNK
ELSATVAELQ AALEAERRSK SALEILLRNA ERSRDEALTR NQQLNREIQE FLNKPTAGPS
//
