ID A2CEX6_DANRE Unreviewed; 1010 AA.
AC A2CEX6; A0A8N7URB3;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN Name=hira {ECO:0000313|Ensembl:ENSDARP00000119160,
GN ECO:0000313|RefSeq:XP_696478.2,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-6296};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000119160};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000119160, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119160};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000119160}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119160};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_696478.2}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_696478.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; CR774200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_696478.2; XM_691386.7.
DR STRING; 7955.ENSDARP00000119160; -.
DR PaxDb; 7955-ENSDARP00000119160; -.
DR PeptideAtlas; A2CEX6; -.
DR Ensembl; ENSDART00000132164; ENSDARP00000119160; ENSDARG00000013434.
DR Ensembl; ENSDART00000132164.2; ENSDARP00000119160.1; ENSDARG00000013434.10.
DR GeneID; 568076; -.
DR KEGG; dre:568076; -.
DR AGR; ZFIN:ZDB-GENE-030131-6296; -.
DR CTD; 7290; -.
DR ZFIN; ZDB-GENE-030131-6296; hira.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_0_0_1; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 5478541at2759; -.
DR PhylomeDB; A2CEX6; -.
DR TreeFam; TF323161; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000013434; Expressed in testis and 27 other cell types or tissues.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 1: Evidence at protein level;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A2CEX6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 66..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 127..159
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..201
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 757..955
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 406..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 111241 MW; 9099A95F7A732AEB CRC64;
MKLLKPSWVN HNGKPIFSVD IHPDGTKFAT GGQGEDSGKV VIWNMAPVLR EEDEKNENIP
KLLCQMDNHL ACVNCVRWSN NGLYLASGGD DKLVMVWKRA AFIGPSTVFG SSSKLANVEQ
WRCVTILRNH TGDVMDVAWS PHDVWLASCS VDNTIVIWNA RKFPEIVMTL KGHTGLVKGL
TWDPVGKYIA SQADDHSLKV WRTMDWQLET NITKPFSECG GTTHVLRLSW SPDGQYLVSA
HAMNNSGPTA QIIERDGWKT NMDFVGHRKA VTVVKFNPKI FKKKQKNGST PKPSCPYCCC
AVGSKDRSLS VWLTSLKRPL VVIHDLFDKS IMDITWTLNG LGLLVCSMDG TVAFLDFSQD
ELGDPLNEEE KNAIHQNIYG KSLAITMESQ LSTTIIENPE MLKYQQERQG NQNANVAQGS
GPENQTPKLT NVLNGESLED IRKNLLKKQV ETRTADGRRR ITPLCIAQLD TGDFSPALFN
SVPILPGSSA STQLTPQISS DSNTANSLGL RPSHDPSTTS PNKTAEENKD SATAPVNSIG
MKSTLLLTSA SKIEPMKALD SRFTERSKAT PGVTSVPITI GITPLDRAKD SSSVKEPKGK
DETSSDSEDK IMNKTLSMAK RKGEIEGGEV VEKRKKGRPR KDAKMMMPIS QPFPQTPVSV
KEELPRLATP AVVLKLPTPS IQKSFSTQVG TDAVTYLEVE NEVSVVSGAR LSQLKWRREG
REWDTLLPSR IIIATGSSDV VAVACEDRTL SVFTACGRRL IPSIMLPAPM SALHCSGHFV
MALMASATLS VWDVQKQTAL VKNESLNPIL SGTDATVSQS LITQQGVAVV SLSNGKTYCF
NSSLETWNLI ADKQDSLVQC ADFRNCLSSQ DVLGSMGPLA LTQGRNLSAG RLASRLSSTP
HHLQQGMTLA FLENQLSSAL MLLSASEYRH WLLIYARFLV NEGYEHRLRE LCQDLLGPVH
KSSSSSWEST VLGLRKRDLL TEVLPVIGQN LRFQRLFTEY QDQLELLRLK
//
