ID A2QDK9_ASPNC Unreviewed; 951 AA.
AC A2QDK9;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Contig An02c0210, genomic contig {ECO:0000313|EMBL:CAK37710.1};
GN ORFNames=An02g07460 {ECO:0000313|EMBL:CAK37710.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK37710.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK37710.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; AM270016; CAK37710.1; -; Genomic_DNA.
DR RefSeq; XP_001399880.1; XM_001399843.1.
DR AlphaFoldDB; A2QDK9; -.
DR EnsemblFungi; CAK37710; CAK37710; An02g07460.
DR GeneID; 4979235; -.
DR KEGG; ang:An02g07460; -.
DR HOGENOM; CLU_009187_1_0_1; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000006706; Chromosome 4R.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 480..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..184
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 207..373
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 384..665
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 276..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 929..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 303..330
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 841..867
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 107660 MW; C00E791D1A0EA00D CRC64;
MHPSALQQRD DDPTEQFLKL ISNPFSSAFQ VNAIWASLAT SAGFSILLAL LFSLFRPRHS
VVYAPKVKHA DNKHTPPPVG RGFFAWLKPV LRTKEPALVE CIGLDATMFV RFTKMCRNIF
IFLSIIGCGL MIPLNLTQST GDTVSQYGAF STMTVLYVTS NAIWGQVICA WAFDAIIAFF
LWRNYKGVLA LRRKYFESSE YQRSLHARTL MITDIPPAAR GDEGVLRLTD EVNPTAAVPR
ASIGRNVKGL PRLIKEHDET VRELEAVLAK YLKHPDRLPP KRPTMRPPRK ERKEHTNGRV
DAIDYLTDKI KRLEEEIKHV RSSIDRRNAM PFGFVSWDMI EHAHAVAYTA RKKHPEGTTI
VLAPRPDDLI WENLPLSKAA RKWKRFLSAI WVSLLTLVYV VPNGLIAIFL SNLNNLASVW
PAFKTSMDNS PYIWAAVQGI LSPAVTSLVY IVLPIIFRRL AIRAGDVTKT SRERHVLNKL
YTFFVFNNLI VFSLFSAAWT FVSAVIDAER SDENAWQAIK DGKLYIKIVN ALCQVSPFWV
TYLLQRNLGA TIDLIQLVSV FWVWFSKTFL SPTPRQAIEW TAPPAFDYAS YYNYFLFYAT
VALCFATLQP IVLPVTALYF GLDAMMKKYM LLYVFVTKTE SGGQFWRVLF NRMLFAVILS
NIIIIIVATA KGTWTMVYCV IPPPLLMLAF KFYCMRKFDD DITFYNRANL TDAEALAVSK
PNKKASERLN SKFGHPALYK PLITPMVHAK AAEALKRIYS GRLGTFEGEG EYSDIAMDAM
SSSHPGKSMM DNADPAPFEV VPENHLDFSY YKNRPDFRDE FGGGIYGRPD DLMTERSHTP
ASALGEWSPT SSRASSPAPS LPSSLSGLKP HDTYDPTLNE HIHPAFRVPA PMSGGFYQQR
NESETELLHH AQGPAVNETV TPLDRWRTRG YGPVEQDDPS FTSYEHYRMP R
//
