ID A2QLH9_ASPNC Unreviewed; 4722 AA.
AC A2QLH9;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Contig An06c0070, genomic contig {ECO:0000313|EMBL:CAK39198.1};
GN ORFNames=An06g01300 {ECO:0000313|EMBL:CAK39198.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK39198.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK39198.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; AM270113; CAK39198.1; -; Genomic_DNA.
DR RefSeq; XP_001390952.1; XM_001390915.1.
DR EnsemblFungi; CAK39198; CAK39198; An06g01300.
DR GeneID; 4981129; -.
DR KEGG; ang:An06g01300; -.
DR HOGENOM; CLU_000092_1_0_1; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000006706; Chromosome 8ER.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 3.
DR CDD; cd19542; CT_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706}.
FT DOMAIN 817..894
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1940..2016
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3061..3137
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3609..3682
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4169..4242
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4722 AA; 517733 MW; C84F29C8CCE09436 CRC64;
MAAPVVPVTR VPALDTLDQY VVGKAAADKA AISPSVELTC SSDYCDIANS LIEGYARFIS
RLTGLEDVAF FVSRQSSIAS ESDLLRGVVS ASVLAAEEGQ QPRCVFREDS EQHADEGEVQ
FSLDLGLYVG PENGEQQPLV GVRDSAFTTF IRPTTTKDTL EISFAYPTRL IPEPAVDQLL
RILATQLADS TTFLTFDAPS PNLSVLNFPP LMIPPLRETD QVDFPESGHS KQYLLHVAFE
GWARRKPDAI ALDFVHSLPS ATAAAEHSLL TYAALNQAAT ILAVHIRALL LAKNAADYGR
IIPVYMPSCP ELYITYLAVL KAGFAFSPIP QDAPVQRVRD VLEDIDCPII LGNTPEPVSG
PWCDASAGST IKQVWVDVAE VSRWKSLRDG QSESSEHGEP LEQLDIEHDQ TAYLLFTSGS
TGKPKGVQIS HLAAACSIEA HATEVPIPGE EIDDFRWFQF CAPTFDPSLA EIFVTLGCGA
TLCSADRSLT LTDLEATINE ARATVMMATP SLAALLRPER LTTLQYLWCI GEKLNRTVIE
NFSAKPGTNG GITVSEPSRM LVNTYGPTEA TIACTYLAPF GHSLRCSIIG QALATCSMFV
LDPNSREPRA VPAGLAGELA IGGPQLSKGY LNRPVETAKA FVDSGEFGRL YRTGDMARMV
WDESGSQIIE FLGRITSDQV KISGRRLELG EIESVLETVR GANEVVAVVS KRDANVQGSE
QIVACLVANG SSEAEREDII WEAHQNSEKH LSSYMCPSAY VFLDALPRSS AGKVDRKAVT
ARLQQGSGGD IRLYPAPKLK PAETNGIHDD WNFLIDEDLL SIQQLIVGLI AEATDESVSA
IKPGTDLYSL GIDSLGAMRL LQKLRDHSIE GLSVGDVLQS GTPKALVNAV AQQRQSNGIP
QVNGSDETLQ HSLSAFQDRN HTICAERLGM TPEKIQKVLP TTATQSGILT SFLRSSSDAA
FATRSYIYHS VLPLEPGVDI DRIKAAWETV IASYDSFRTV FCWLDDDMAP FAQCILAPTA
VSGTRWNTYH STKQSSDENV LQQALQEAEE SIELGTPPWR LSVVTSPAST RIILSMFHGI
FDGGSLQLLL EDVSSVYSGN TPAQRVSLEH LVKHHFQADH AATAKFWGQH LESYSPVWFP
SVTPYRTPPT KKTGCVEITA RTSYDRLKRE SKLIGSTPLS VLQAAWGSVL LAYTGTPAQD
VVMGSVVSGR LDVDSETCVG PTFTTVPIRL SLSQIQQDSQ KSWTNRSVAR HLTTFNAQTL
SHLQPRLGSL VTADGRLPYD TLIAYQDFNA GSSVSGLWSS VDHPAMANDF AVMIEIWPAA
NSSLTFRASF NDVLLDRNSA EMMLWQMSDI VAYILEQPDE SFQDAPSHTE TGLKSSFNSK
PSIAPEVLDG ALLHSQFEEH AASHPEDPAL IFKYDLDDES NPRNITWSYA GLNALADKLA
EHLLQTGARV ANSPIPICIE KSPALYVAIL GILKAGGAWC PIDTLSPAQR RHDLIARTGS
TILLVSSVDG EQPDGSIPIG VETIDVGKFT IDEPIYANGV VRGASRDRAT PDGMAYLIWT
SGTTGAPKGV PIKHSSAVSS MRSLQKDIPT DVAGGVRCLQ FSQYTFDVSI QDIFYTWGVG
GVLISASREI MLGSFSKLAN ITNATHAHLT PAFSAGVSRK SCPTLQVITM IGEKLTQPVA
DDWGTDMRAF NTYGPAEVTV VSTIREFGNE HKNIKSANIG WPMDTVSVFV TNKQRLIMKN
AIGELALGGP QLSPGYLNQE DVTKAKYVWN EEVGQMVYYT GDLVRMLADG SLEYINRVDD
LVKLGGIRVE LSEISFSLGE CHPLVENIET LILNRPDRPN KVVVAFLSAP KATRTEDEQL
LMIDKAALEI ARAASEKAQS VLPDHMIPSV YLVVSHIPRT SSAKTDRRAL EAAYAGVDID
SWEKEMNPEI KSSAADSQDQ HTATITHRVV EMISTLANIS QSIITKSSRL GSLGIDSIRA
IRLASRLKEA GHQLSVVEVL NCVTVQDLVQ LASSSTVVEK PTYETFDVRA FHDTWHTATV
SKVPEGFITV RATTIQESLL SETMGTYNRY WSNHFFLLDS SVDATRMKQA WLATSQKVEA
LRTGFIPVAE VDDGKSRSQG KLDFSILQII YTLPDVDWEY INCSEQDLVE HRENRIEEIM
TKHQKNYFKY PPWAVTVFDT GKRQLMILTL HHSIHDEPSL GLIMDDVRSA YAYKPPQRHQ
LSDALSIVLP GENRSKETRS FWKTELKKFA ELDAPVWPDL TGKRLQPGEV PKHILITEES
PLTEPVGNLQ SFAAQLGVSS IASIIRAAWA FVSLAYLGLP ATVFAETLSD RVLHADLEDC
IGPLISVVPI PFHPTGNTRE LLTEQHRISV HSWKYRHIHA REVRKILKRP RGEALYPAVF
NFHVAKEEGA NVTQPSIWRE LEDEVGLHVE HPMAMNVFQH MDGSIVLEAT ADSSIMCRAQ
LSLFIRQIDG LISSMLASPD QPLASLINRF PSPLRSLSNQ PVREEVVKSV RLSPTHWLEV
YAKKHPEWTA VEVASEISSN GIVKEAMTFG TLNSEANRVA AYLASLGHKN RMIGVCIGRN
LPSYPIIIGI FKSGNAYLPI EENLPEDRKA FLIKDSDCPV VFTETAFVST LQSTPEGCRV
ITIDNPELLG SLATMSTEDQ DYNSDPNDLA YLLFTSGSTG KPKGVMVTRG NLSSFIESIS
VFTGRYAPAT YDLGGTGRYL AQASRAFDPH LLEMLFPWRH GMATVTAPRM MILDDLGITL
SKWDITHASL VPSLLDQANI VPEQCPKLRF MTVGGEKISQ KVLDTWAGTP HMALINAYGP
TEVTIGCTFA PVGKDTNLRN IGPPLAACVS HVLVPGTLDY ALRGQAGELC FSGDLVGRGY
LNRPDATGFI TGPNGEKMYR TGDLGRMMPD DSVEYLGRGD DQTKIRGQRL ELGEVSEVLR
SSSTVGIDVV TTVAKHPGLS RVQLISFIAR SEARQRVKSG DVTFVMSDFA TLGKELQDSC
KRKLPGYMVP ELILPITYIP LAPMSGKANI KELHGLFSSL PLPTVLQGNS SASKDGVVIE
RPLTADEEAV IKEVLDVVSA DPSIVRPMTN IFEVGLDSLS AIGLTIKLRR IGYEVTVAMV
MSNPIIEQLA RLPRGSSDAE SAVSQTRQAF QNIESQYRQQ PSPGVNPSDV DTVRPCLPLQ
EGLVARSINS ESDQLYVNHI ALQLEACVDS EKLKSAWQAV SNDTEILRTL FAPLDKQMVQ
VVYTVDSHQF PWKEEEYESL NEAIEHNKAQ QKQISEEIIA NISTVPPVRF LIAKSSETKE
PLALFINIHH ALYDGESFTM LMEDVAARYA DQPIPQRGSP SAFVEYVYSQ DSEKAKQHWV
RYLEGCHPTT FRTDFNAMEP PVVVHRSLGV KLSELEHRSA ALQTTVPSLV QAIFALLLAD
TVGVSDVTYG LVLSGRAVSV PGASSVLLPC ITTVPGRLNT ASLSTVDDVV ADVQKSTVGS
LDFQHTPLRH IQRWINAEAP LFDCLFSYIR TAAPPEHRLW QELESNMPAE YPLAVEVEAN
HSMDTVQLNC FFSSAFGSLY NGSELIEKMD AVLSSIAAGQ SLSLDDFNVS HSAASGSRPA
VLWDNTTWST AETTIREYTM SFCGLTSVEV TKGASFLSLG VDSVTAIQFA RQLREAGLQV
SSADIMRFSC VGALAQHVEQ KSRSQTPVNG TNGHEKTITG IPIETYGENV RLLAEDDSIS
TMFETTPLQS GMITQTIASS GKVYAHPHII RLKDSVDTTR LKEALFRVID ANDILRTSFH
LIAELGSSWI AAVHTNPPFQ WEELTLPSGA DVLTEVDSLY DFSEEASFEV PPIRSALVNQ
PGGRLLVVVL HHALYDGSSI PFLFEDLAVC YEESSLPIRP QFSETVQHLL SGQEKACEFW
TERLLGYEVT ELPELPHPES SDRMLLSECR VDLDLSAIVD ACKAMEVTVQ SVSLLAYAKV
LAGVVGKRDV VFGQVLAGRS LPVAGAERTL GPMFNTVAQR VSFEPKFLSN KAMAQRLQQH
TIDSQSHQNA PLRLVQNSFR QANNSTSSML FDTLFVFQKS ADFAGSIIEE QQIWTPYEAD
DYAAQAEYKL NVEVDHACDG LVVQATCNGR YISQETLDQL MDEFAIAFRD IIEHPTRCAT
IVPQGLGELP TKLSVEQSLD PNVESSEAPS HEAIIQSVLA EIAGISVDNI KPNTSIFNIG
LDSLTAIRIA SICRSKGLKI GVADILQGNT LRGISQRIQP LSEQAIQPRG SLIRNYTEVE
TTVLQQLNLS KDSVEAILPC LGGQFYHLVS WLKSGRNLLE PAWAYACSGR IDSAKIEEAW
FQLRQRHPIL RTCFAAISSS EAVQIVLKQA MRGAGTFQVI ETSTPLFEAA QAQAREEALH
PSSLFTPPVR LRLLKANDRD GILLLINHAA YDAWTMPLFV KELAELYNDQ RPVANTDFPA
FVDFSMRSLQ SLDEKQYWNT TLGDASPTII RNTRTETQPT PDQLFIGVWE KVKDLSQLET
KCRSSNVSLQ TVVLFAIARC IARLTNVQNP TMGLYQAGRS ASFNNVENLS GPCLNVNPFT
IPNADTNPID TDLLTQVRAI QSSLADRVSY EQSSLRNILQ WISPEKPLFN TWVNLLWTQN
TISSNAKSTS DGTEDFFSPL RIGVPTDFIP EQPLAEEVTA VSALDTEFLP SENVFIDVGP
DAKTDSIGFG VRVEGGVMSV EEVHKLVDEI AGEIERTMGM LA
//
