ID A2QPT1_ASPNC Unreviewed; 1072 AA.
AC A2QPT1;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Contig An08c0010, genomic contig {ECO:0000313|EMBL:CAK39766.1};
GN ORFNames=An08g00070 {ECO:0000313|EMBL:CAK39766.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK39766.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK39766.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease. {ECO:0000256|ARBA:ARBA00025147}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|ARBA:ARBA00009466}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM270156; CAK39766.1; -; Genomic_DNA.
DR RefSeq; XP_001392127.1; XM_001392090.2.
DR AlphaFoldDB; A2QPT1; -.
DR EnsemblFungi; CAK39766; CAK39766; An08g00070.
DR GeneID; 4982323; -.
DR KEGG; ang:An08g00070; -.
DR VEuPathDB; FungiDB:An08g00070; -.
DR HOGENOM; CLU_011906_0_0_1; -.
DR OrthoDB; 169519at2759; -.
DR Proteomes; UP000006706; Chromosome 8R.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0005816; C:spindle pole body; IEA:EnsemblFungi.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030619; F:U1 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030620; F:U2 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030621; F:U4 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0017070; F:U6 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006611; P:protein export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
DR GO; GO:0000055; P:ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR041123; CRM1_repeat.
DR InterPro; IPR041235; Exp1_repeat_2.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR045065; XPO1/5.
DR InterPro; IPR014877; XPO1_C_dom.
DR InterPro; IPR040485; XPO1_repeat_3.
DR PANTHER; PTHR11223; EXPORTIN 1/5; 1.
DR PANTHER; PTHR11223:SF2; EXPORTIN-1; 1.
DR Pfam; PF08767; CRM1_C; 1.
DR Pfam; PF18777; CRM1_repeat; 1.
DR Pfam; PF18784; CRM1_repeat_2; 1.
DR Pfam; PF18787; CRM1_repeat_3; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM01102; CRM1_C; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 26..92
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1072 AA; 123301 MW; 7BBFE0D8E26F9A1D CRC64;
MSVSIQELDN TVRAFYEGKG DLQKQAQQTL TEFKQNPDAW LIVGNILQES TYPQTKYLAL
QVLDDVIMTR WKVLPREQCL GIRNFIVNFI IENSKSEDKL RSERAFLNKL NLVLVSILKQ
EWPHNWPTFI NEIISSCHTS LSICENNMAI LRLLSEEVFD FSQDQMTSVK ARNLKTSMTQ
EFSSIFQLCS EVLNTANQPS LIKATLETLL RFLNWIPLGY IFETPIINTL LTRFLDVPEF
RNVTLKCLTE IGGLQIGNPY NYDERLVHMF TETLTAVSRI IPLSMDLKQT YAKSNSRDQE
FVLNLALFLS SFFSAHLNLI EKLPNRDYLT HAHFYLIRIS QIDDREVFKI CLEYWTRLVQ
ELYEEMQQLP ITDINPLVSM GVSGLSNGGA PHPSTLANYP LRKHKYEEVL SSLRTVMIEK
MVRPEEVLIV ENDEGEIVRE FVKESDTIQL YKTIRECLVY LTHLDVVDTE NIMIEKLAKQ
VDGSEWSWAN CNTLCWAIGS ISGAMNEETE KRFLVNVIKD LLGLTEMKRG KDNKAVVASN
IMYIVGQYPR FLKAHWKFLK TVVNKLFEFM HETHEGVQDM ACDTFIKIAN KCRRHFVALQ
PGENEPFIEE IVRNMRKITC DLSPQQVHTF YEACGYMISA QGQKGLQDRL IENLMSLPNS
AWDAIIVQAN QNPAILQDGE TIKIIGNIMK TNVAACSSVG TYFYSQLGRI YHDMLNMFRA
SSQLISDAVA HDGNIATKTP KVRGLRTIKK EILKLIDTYV QKADDLEMVN ANMVPPLLEA
VLVDYNRNVP DAREAEVLNV MTTIIHKLHN LMEDKVPLIM ESVFECTLGM INKDFHDYPE
HRVQFFKLIQ AINLYCFPAL LKLDATQFKF VIDSCMWASK HDNREVENTG LTMCLELMNN
MADTDAQTSN IFFQQFYIPI LQDVFFVLTD SDHKAGFKSQ AMLLSRMFYF IESGKVQNPI
YSPEQAPLGT SNKDFLQEYV ANLLQNAFKN LQEIQIKQFV VGLFAFNDDF NKFKTHLRDF
LISLKEFSGD NADLYAEERE QALRDAKAAE RDRAMRVGGL LKPSEMDQED EL
//
