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Database: UniProt
Entry: A2QX45
LinkDB: A2QX45
Original site: A2QX45 
ID   DCL22_ASPNC             Reviewed;        1362 AA.
AC   A2QX45;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   31-JUL-2019, entry version 75.
DE   RecName: Full=Dicer-like protein 2-2;
DE   Includes:
DE     RecName: Full=Endoribonuclease dcl2-2;
DE              EC=3.1.26.-;
DE   Includes:
DE     RecName: Full=ATP-dependent helicase dcl2-2;
DE              EC=3.6.4.-;
GN   Name=dcl2-2; ORFNames=An11g07590;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G.,
RA   Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K.,
RA   Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M.,
RA   Breestraat S., Caddick M.X., Contreras R., Cornell M., Coutinho P.M.,
RA   Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M.,
RA   van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S.,
RA   Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T.,
RA   Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M.,
RA   van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P.,
RA   van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C.,
RA   Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G.,
RA   Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U.,
RA   Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B.,
RA   Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory
RT   Aspergillus niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Dicer-like endonuclease involved in cleaving double-
CC       stranded RNA in the RNA interference (RNAi) pathway. Produces 21
CC       to 25 bp dsRNAs (siRNAs) which target the selective destruction of
CC       homologous RNAs leading to sequence-specific suppression of gene
CC       expression, called post-transcriptional gene silencing (PTGS).
CC       Part of a broad host defense response against viral infection and
CC       transposons (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000255|PROSITE-ProRule:PRU00657}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK40801.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AM270243; CAK40801.1; ALT_SEQ; Genomic_DNA.
DR   PaxDb; A2QX45; -.
DR   PRIDE; A2QX45; -.
DR   EnsemblFungi; CAK40801; CAK40801; An11g07590.
DR   HOGENOM; HOG000129941; -.
DR   Proteomes; UP000006706; Chromosome 7R.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Antiviral defense; Antiviral protein; ATP-binding; Complete proteome;
KW   Helicase; Hydrolase; Nucleotide-binding; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN         1   1362       Dicer-like protein 2-2.
FT                                /FTId=PRO_0000306788.
FT   DOMAIN       30    197       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      343    505       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   DOMAIN      536    630       Dicer dsRNA-binding fold.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00657}.
FT   DOMAIN      889   1033       RNase III 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00177}.
FT   DOMAIN     1075   1258       RNase III 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00177}.
FT   NP_BIND      43     50       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       139    142       DEAH box.
SQ   SEQUENCE   1362 AA;  153885 MW;  D233E94793C21EB3 CRC64;
     MTSSTDYHAD STPGTTSNME LRIREYQLEM LNESLKRNLI VVMPTGTGKT QVAILRILAD
     IDKGNSDKFV WLLCPTVALS EQQYIQYATV FLPSGAEDKA IWDNALSGIK IAVSTYQVLY
     DALSHGFVKL SQMSLLIFDE AHHCKKDHVA NKIMQVHYHK QHQSGVQNLP KILGLTASPI
     LSDLSSLEIV ESNLGSICKT PRQYYAQLLQ FTNRPLILPR LPTYTIPNCS VKAPILEKLC
     GILSSEDEVP SSSKMKSKQL KHIRRFMQTS ESINQELGIW AATEYMRKSI MHFKESMRMG
     AEKTNISNYG KDFAMEILTR LGKLQDCSPA IQPEEISPMC QCLLDELSKA YREGFCGLVF
     VTQRATVLAL KWLIENHPLT SHLFTCGTFI GMSTTQYSKT ELGNLHDIRN QTETLEKFRQ
     GSLNLIITTD ALEEGIDVPA CNTVLNFNCQ LSLKSFIQRR GRARRENSQF IIIMEDESGP
     RYLKRLEMEE IELVQKLQNA ERRQIPANEL DFDKYERISL SLDIDRTGAQ LIMREAVGYL
     YNFCSKLPAQ LYVSNKPLFT YERNNYGRFR AVVKLPSNLD PSLQSFSSSR SWSRLKYARE
     DAALQAYKAL YQAGLVNDYL VPTQVSDHLE GDIIFRSHYS IQNQLDPWQD IALLWKLDSQ
     LYAHNLRIIR PEEDEIHLHM ILPTQLDTTI HIPLFIDYCT TYTAILTPGH PITTDISLCQ
     QVTNLIFQSV YRDHCSRRNL DYAFLLVPEL EETKLIEFLE RYSGSVSLTE LLNQEATPSA
     LGLLRSHTRP SRPLLVEPWV AGECFLPDEL SISSFDAKVK YMTNRRNFLS HGNLAAGKST
     NCEARIGLEA NVKSMSVRDF FVDKLPSMFA QVALFTPSIS HEVEVYMIAQ ILRQELSLRS
     VTPWQRIDLL AIAIRPTSIE HRATFRLLAF IGDAFMKYLF AMQLFLHHHL WHEGLLSSLK
     QRNLSDAGLA HAIHQSGLGK FLISKHLNGK RWVPPLVSGI EPASNEARQR SIGAATLADM
     TKAVVGAAFT DGGLNQAAAC ASVMFPKLKS WNASSLHDGT YSKTRPENAV ASTAIVDMEE
     LLGYTFTDKS LAVESMTHPS CTGLVQTTSY RRLSFLGASV LEWIVVSYLH RHAQVMNPQR
     MQSLKSAFTN NTFLTFIAIT FHQVREQNHI DVDDEHNVHK NVTTCSIRLW DFLRLHSDAL
     STELSDFVQK SSEKADAIKH ELWEQRFYPW VRLRALGDMR VLSDIIQSIF GAVFIDSQAT
     LASCDALAEK LGIVPLLEHF ISHQITTDHP KDTLQAILPG RKVSYQICVD KVHPGTLRCS
     ALADSSEIAS VEGQMNDEVI KMQAAETAVR LLRKGFALSE TS
//
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