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Database: UniProt
Entry: A2R1A6_ASPNC
LinkDB: A2R1A6_ASPNC
Original site: A2R1A6_ASPNC 
ID   A2R1A6_ASPNC            Unreviewed;       371 AA.
AC   A2R1A6;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=An13g00550 {ECO:0000313|EMBL:CAK41456.1};
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=425011 {ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK41456.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G.,
RA   Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K.,
RA   Andersen M.R., Bendtsen J.D., Benen J.A., van den Berg M.,
RA   Breestraat S., Caddick M.X., Contreras R., Cornell M., Coutinho P.M.,
RA   Danchin E.G., Debets A.J., Dekker P., van Dijck P.W., van Dijk A.,
RA   Dijkhuizen L., Driessen A.J., d'Enfert C., Geysens S., Goosen C.,
RA   Groot G.S., de Groot P.W., Guillemette T., Henrissat B., Herweijer M.,
RA   van den Hombergh J.P., van den Hondel C.A., van der Heijden R.T.,
RA   van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P.,
RA   van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J., Meulenberg R.,
RA   Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M.,
RA   Pal K., van Peij N.N., Ram A.F., Rinas U., Roubos J.A., Sagt C.M.,
RA   Schmoll M., Sun J., Ussery D., Varga J., Vervecken W.,
RA   van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory
RT   Aspergillus niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; AM270296; CAK41456.1; -; Genomic_DNA.
DR   RefSeq; XP_001396195.1; XM_001396158.2.
DR   PaxDb; A2R1A6; -.
DR   EnsemblFungi; CAK41456; CAK41456; An13g00550.
DR   GeneID; 4986503; -.
DR   KEGG; ang:ANI_1_68114; -.
DR   HOGENOM; HOG000220501; -.
DR   KO; K01626; -.
DR   Proteomes; UP000006706; Chromosome 2L.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006706};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000313|EMBL:CAK41456.1}.
FT   DOMAIN       46    346       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   371 AA;  40221 MW;  BA0D36C369EE515E CRC64;
     MPLISTTEVN EDTRVLGYDP LLPPQYLQNE IPGKKESLEA VRSGRNQAMK IIEKRDDRLL
     VVVGPCSIHD PATALEYAQR LKELSEKLSD DLCVIMRAYL EKPRTTVGWK GLINDPDIDE
     SYNINKGLRV SRQLYADLTS MGMPIASEML DTISPQYLAD LISLGAIGAR TTESQLHREL
     ASGLSFPIGF KNGTDGNLTV AIDAIGAAAH PHRFLGVTKQ GLAAITKTAG NEHGFVILRG
     GNKGTNYDRE SIKAAREALA GKKQPEVVMV DCSHGNSNKN HRNQPLVAKE VSDQLREGQD
     AIIGVMIESN INEGNQKVPP EGPSGLRKGV SITDACIDWE TTVQVLEDLA DGVRARRAAK
     AAQAKASNGT H
//
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