ID A2RRV4_DANRE Unreviewed; 604 AA.
AC A2RRV4; A0A8M1NFE3;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=Kelch-like 8 (Drosophila) {ECO:0000313|EMBL:AAI31870.1};
DE SubName: Full=Kelch-like family member 8 {ECO:0000313|Ensembl:ENSDARP00000135163};
DE SubName: Full=Kelch-like protein 8 {ECO:0000313|RefSeq:NP_001103950.1};
GN Name=klhl8 {ECO:0000313|EMBL:AAI31870.1,
GN ECO:0000313|Ensembl:ENSDARP00000135163,
GN ECO:0000313|RefSeq:NP_001103950.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070209-226};
GN Synonyms=zgc:158266 {ECO:0000313|RefSeq:NP_001103950.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI31870.1};
RN [1] {ECO:0000313|EMBL:AAI31870.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI31870.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001103950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103950.1};
RX PubMed=21047546;
RA Gautier A., Le Gac F., Lareyre J.J.;
RT "The gsdf gene locus harbors evolutionary conserved and clustered genes
RT preferentially expressed in fish previtellogenic oocytes.";
RL Gene 472:7-17(2011).
RN [3] {ECO:0000313|RefSeq:NP_001103950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103950.1};
RX PubMed=23843192; DOI=10.1093/gbe/evt104;
RA Feiner N., Murakami Y., Breithut L., Mazan S., Meyer A., Kuraku S.;
RT "Saltatory evolution of the ectodermal neural cortex gene family at the
RT vertebrate origin.";
RL Genome Biol. Evol. 5:1485-1502(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000135163, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135163};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000135163}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135163};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001103950.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001103950.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; CABZ01072038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC131869; AAI31870.1; -; mRNA.
DR RefSeq; NP_001103950.1; NM_001110480.2.
DR STRING; 7955.ENSDARP00000135163; -.
DR PaxDb; 7955-ENSDARP00000011409; -.
DR Ensembl; ENSDART00000157614.2; ENSDARP00000135163.1; ENSDARG00000101270.3.
DR GeneID; 572347; -.
DR KEGG; dre:572347; -.
DR AGR; ZFIN:ZDB-GENE-070209-226; -.
DR CTD; 57563; -.
DR ZFIN; ZDB-GENE-070209-226; klhl8.
DR eggNOG; KOG4441; Eukaryota.
DR HOGENOM; CLU_004253_14_2_1; -.
DR OMA; YRAAIKW; -.
DR OrthoDB; 5472491at2759; -.
DR TreeFam; TF329218; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000101270; Expressed in mature ovarian follicle and 21 other cell types or tissues.
DR CDD; cd18448; BACK_KLHL8; 1.
DR CDD; cd18238; BTB_POZ_KLHL8; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF480; KELCH-LIKE PROTEIN 8; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A2RRV4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 51..118
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 66848 MW; EB3FBFBFB107C03D CRC64;
MVPEHGKQQK RSPQPSNSEA DADGSFVFEA QEAWKDFHNS LRQFYENGEL CDVTLKVGNR
LIPCHKLVLA CVVPYFRAMF LSDMAEAKQD LIEIRDFDAD AIQDLVRFAY SSRLTLTVDN
VQPLLYAACI LQVELIARAC CEYMKAHFHP SNCLAVRTFA ESHNRVDLMD MADRYACEHF
SQVVECEDFV CVSPQHLKTL LASSDLNIQA ETQVYNAAVK WLRANQKHHA VWLDQIMAQV
RLPLLPVEFL TATVAKEEMI KASLSCRDLL DEARNYHLHL SNKSVPDFQY SVRTTARKHT
AGVLFCVGGR GGSGDPFRSI ECYSISKNSW FFGPEMNSRR RHVGVISVAG KVYAVGGHDG
NEHLGSMEMF DPHTNKWMMR ASMNTKRRGI ALAALGGPLY AIGGLDDNSC FSDVERYDIE
CDRWSAVAAM NTPRGGVGSV ALGGFVYAVG GNDGVASLSS VERFDPHLNK WTEVREMGQR
RAGNGVSELH GCLYVVGGFD DNSPLSSVER FDPRLNRWDY VCELTTPRGG VGVATVMGRV
FAVGGHNGNI YLNTVEAFEP RMNRWELVGS VSHCRAGAGV AVCSTLISQV RDVGQGSSNV
ADCM
//
