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Database: UniProt
Entry: A2RUZ0_DANRE
LinkDB: A2RUZ0_DANRE
Original site: A2RUZ0_DANRE 
ID   A2RUZ0_DANRE            Unreviewed;       906 AA.
AC   A2RUZ0; A0A0R4IQ02;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   18-JUL-2018, entry version 101.
DE   SubName: Full=SH2B adaptor protein 1 {ECO:0000313|Ensembl:ENSDARP00000078411};
DE   SubName: Full=Zgc:158474 protein {ECO:0000313|EMBL:AAI33103.1};
GN   Name=sh2b1 {ECO:0000313|Ensembl:ENSDARP00000078411,
GN   ECO:0000313|ZFIN:ZDB-GENE-070209-188};
GN   Synonyms=zgc:158474 {ECO:0000313|EMBL:AAI33103.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI33103.1};
RN   [1] {ECO:0000313|EMBL:AAI33103.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAI33103.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000078411}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078411};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000078411, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000078411,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000136345}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136345};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
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DR   EMBL; BX784026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC133102; AAI33103.1; -; mRNA.
DR   RefSeq; NP_001103925.1; NM_001110455.1.
DR   RefSeq; XP_017209841.1; XM_017354352.1.
DR   RefSeq; XP_017209842.1; XM_017354353.1.
DR   UniGene; Dr.132512; -.
DR   STRING; 7955.ENSDARP00000115931; -.
DR   Ensembl; ENSDART00000083976; ENSDARP00000078411; ENSDARG00000057679.
DR   Ensembl; ENSDART00000141808; ENSDARP00000115931; ENSDARG00000057679.
DR   Ensembl; ENSDART00000158487; ENSDARP00000136345; ENSDARG00000113263.
DR   GeneID; 558152; -.
DR   KEGG; dre:558152; -.
DR   CTD; 25970; -.
DR   ZFIN; ZDB-GENE-070209-188; sh2b1.
DR   eggNOG; ENOG410IMWK; Eukaryota.
DR   eggNOG; ENOG41102PH; LUCA.
DR   GeneTree; ENSGT00530000063355; -.
DR   HOGENOM; HOG000214259; -.
DR   KO; K12459; -.
DR   OMA; CFSIVDV; -.
DR   OrthoDB; EOG091G04RI; -.
DR   TreeFam; TF323184; -.
DR   Reactome; R-DRE-1170546; Prolactin receptor signaling.
DR   Reactome; R-DRE-982772; Growth hormone receptor signaling.
DR   Reactome; R-DRE-983231; Factors involved in megakaryocyte development and platelet production.
DR   Proteomes; UP000000437; Unplaced.
DR   Bgee; ENSDARG00000057679; -.
DR   ExpressionAtlas; A0A0R4IQ02; baseline and differential.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd10346; SH2_SH2B_family; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR030521; SH2B1.
DR   InterPro; IPR035057; SH2B1_SH2.
DR   PANTHER; PTHR10872; PTHR10872; 1.
DR   PANTHER; PTHR10872:SF3; PTHR10872:SF3; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF109805; SSF109805; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN      715    813       SH2. {ECO:0000259|PROSITE:PS50001}.
SQ   SEQUENCE   906 AA;  96964 MW;  59ACE48D12EF8AE7 CRC64;
     MNGSLLTPPS PRAAANSSPL PPSPSPSPSP PSPSLLPLST RPPPLPPPTP VGQPLSSLSD
     TPTPSPSPCL SWTEFCELHA RVAAGDFARH FRAFLQENPN YSPDSAALFC RRFTDRFVRH
     FESELEVTGI SREGTVNWVA QSDVTSLEED AASPSLLTAE SAAASCPPIH TRATPKPILT
     QESRGTERFQ NSGGFQDSYA HAQILPPSSS SSCSSSMGGN NGRREERGMA LKHNPSGYKD
     LEEEEDSWAG PVTLEEVETD IIGRDNEGED LERADLTLNP SSAPANSKGN GTPIGGHSKN
     KLKKRFSLRS VGRSVRGSVR GILHWRSSSS DSPQNCSNSS PLPSSYSYTT GLQDGKRNSG
     SQGVPSSLPV SLSLPLSLPH SSSSSLPPSS SSSATSLSLS EARDWRRSNG DGEKEKWSHR
     LEKLRLSRSP PPNLSSAAPP SSVLSPSSLP PSSINASRKM GRLVREGGVT VCSSSDEFAS
     THGFPGFSFG LLHHGADSSV SGHPTAIGGA VGGRGTRWHK CRLVLKERDK DGGDGGLEYF
     LEFYIPPKSS KPRLTVPCCS IVDVRSTTAI EVPDKENTFL LQMEGQVQYV IETRDAVQMR
     AWLSDIRNAI CLSEQEDVDG VCGSALTDLS GTPEFSDRLS QVCYGGVGGS PQLEPLPPEL
     PPRAPLDESD SRLLGGGGAS LGTPFAETPD ATGSFLFSDV SVSETVEHPL SECQWFHGTL
     SRLKAAQLVL AGGMASHGVF LVRQSETRRG EYVLTFNFQG KAKHLRLSLN EDGQCRVQHL
     WFQSIFDMLE HFRVHPIPLE SGGASDVTLI SFVGATNVRQ PDLTSRPRSP PQPPPPPLPP
     GRPPPPTPPQ ERGPEPEVAG GGGASSGAEE CEEREREPAL LQLEGVEGEE REGGRARAID
     NQYSFF
//
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