ID A2SDJ3_METPP Unreviewed; 1170 AA.
AC A2SDJ3;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mpe_A0670 {ECO:0000313|EMBL:ABM93632.1};
OS Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM93632.1, ECO:0000313|Proteomes:UP000000366};
RN [1] {ECO:0000313|EMBL:ABM93632.1, ECO:0000313|Proteomes:UP000000366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC {ECO:0000313|Proteomes:UP000000366};
RX PubMed=17158667; DOI=10.1128/JB.01259-06;
RA Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA Hristova K.R.;
RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT proteobacterium Methylibium petroleiphilum PM1.";
RL J. Bacteriol. 189:1931-1945(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000555; ABM93632.1; -; Genomic_DNA.
DR RefSeq; WP_011828270.1; NC_008825.1.
DR AlphaFoldDB; A2SDJ3; -.
DR STRING; 420662.Mpe_A0670; -.
DR KEGG; mpt:Mpe_A0670; -.
DR eggNOG; COG0784; Bacteria.
DR eggNOG; COG1457; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_008084_1_0_4; -.
DR Proteomes; UP000000366; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:ABM93632.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW Transferase {ECO:0000313|EMBL:ABM93632.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 471..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 630..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 715..929
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 953..1069
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT COILED 681..708
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1003
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1170 AA; 126379 MW; 00C2170D389DD12F CRC64;
MPSHPAALPP ASDTPPAAPV QRVIKLRRDY NSWVARETME DYALRFTPRA FRKWSAWRVA
NTAIGGAASF LVLEAVGATL LVQHGFVNAA LAILVTGLVI FLAGLPVSVY AARHGVDMDL
LTRGAGFGYI GSTLTSLIYA SFTFIFFALE AAVMAYALEL AFDIPPAWGY LICAVVVIPL
VTHGVTAISR LQVWTQPLWL AMLVAPYVYV FAENPGVVDG LLAYGGEKGV AGFSWLHFGA
ATTVGIALIT QMGEQADYLR FMPEKRAGQR GRWWLGVLVG GPGWVLPGVL KMLGGTLLAW
LAISHMVPLD RAVDPNQMYL AAYEHVFPHY GLAVAATALF VVISQLKINV TNAYAGSLAW
SNFFARLTHS HPGRVVWMVF NTAIALMLME LNVFQAIGSV LGLYSNVAIA WMMAVVADLV
VNKPLGLSPP GIEFRRAHLY DVNPVGVGAM GIASLLSITA HIGLYGPMAQ AWSAAIAMVT
AFAAAPLIAW ATKGRYYIAR QPEPLAAGDD GRYPRLSRCC ICEREYERDD IASCPAYGGP
ICSLCCTLDA RCGDLCKPPE AKLAAQWSAA LRRLLPRAVW PYIDTGLGHY LLLMLTVVPL
LGGLFALLYH QELRTLAASG APLAPAVAGA LKLGFVKAFA ALLLIAGTVA WWLVLTHKSR
EVAQEESNRQ TAALRTEIES HRRTDAQLQE AKLQAERAMH QAEQANRAKS RYITAISHEL
RTPLNSILGY AQLLEEDEAM PPHRAQAVRV IRRGGDHLAS LIEDTLDLAR IESGKLALEV
RPLRLCEAVQ ELARMFELQA RAKGLVFRHE IEGPDVVRAD EKRLRQILIN LLGNAVKFTA
QGEVVFRMRY AREIAHFEIE DSGPGMTSDE LARVFEPFER GGALAGGGHG TGIGLTIAKM
LTDLMGGEMT VRSTPGRGTA FAIRLFLPQA SEATVAPAVR VARRIGYAGA RRSVLVVDNE
EADRGLLATV LEPLGFAVRQ AASGEAALRL LRAGPPPDAI LMDLAMPGLD GWATIRQLRE
EGLCEAPVAI VSANAFDRGL DNDVGVTPAD FFVKPVRVTD LLQWLGQRLA LEWIDAPPRH
ATASGPPALA TPAGPLPVAA FARRAALDEL ARLGYLRGLL GELSAIEAED PAAAAWTGPV
RELAQQFRFD AIRALLNPRD EEPEDAAAAA
//
