ID A2SEK0_METPP Unreviewed; 456 AA.
AC A2SEK0;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Putative transmembrane sensor histidine kinase transcription regulator protein {ECO:0000313|EMBL:ABM93989.1};
DE EC=2.7.3.- {ECO:0000313|EMBL:ABM93989.1};
GN OrderedLocusNames=Mpe_A1027 {ECO:0000313|EMBL:ABM93989.1};
OS Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM93989.1, ECO:0000313|Proteomes:UP000000366};
RN [1] {ECO:0000313|EMBL:ABM93989.1, ECO:0000313|Proteomes:UP000000366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC {ECO:0000313|Proteomes:UP000000366};
RX PubMed=17158667; DOI=10.1128/JB.01259-06;
RA Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA Hristova K.R.;
RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT proteobacterium Methylibium petroleiphilum PM1.";
RL J. Bacteriol. 189:1931-1945(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000555; ABM93989.1; -; Genomic_DNA.
DR RefSeq; WP_011828627.1; NC_008825.1.
DR AlphaFoldDB; A2SEK0; -.
DR STRING; 420662.Mpe_A1027; -.
DR KEGG; mpt:Mpe_A1027; -.
DR eggNOG; COG4564; Bacteria.
DR HOGENOM; CLU_000445_20_6_4; -.
DR Proteomes; UP000000366; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR033480; sCache_2.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR InterPro; IPR017171; Sig_transdc_His_kinase_MctS.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF37; SIGNAL TRANSDUCTION HISTIDINE-PROTEIN KINASE_PHOSPHATASE UHPB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF17200; sCache_2; 1.
DR PIRSF; PIRSF037314; STHK_MctS; 1.
DR SMART; SM01049; Cache_2; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ABM93989.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABM93989.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 202..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..132
FT /note="Single Cache"
FT /evidence="ECO:0000259|SMART:SM01049"
FT DOMAIN 354..449
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|SMART:SM00387"
SQ SEQUENCE 456 AA; 50666 MW; 35FADCC551160144 CRC64;
MRLKSKIVLL AVVPLLASIV LIALAVRHQE RALAAREREL VESAYMSSKR TELRHYVELA
RSTIAPLYDS GDDSEATRQA AMKLLASLDY GTDGYFFLYD LQGRSLMHPR QPELVGNDLW
ELRDEAGHPT IQQLIAKASE GGGFIDYLWR KPSTRQTTPK LGYVIALPRW NWMLGTGLYL
DDVQATMAQL DHQVAANIET TFLWIAGIAL SGIALITVCG LALNLSEHKE ADAKLRQLAQ
QVVQSQESER AHLSRELHDG TSQTLVSIKL LIESAIEQIE REPAQAAVPL ERAAVRLADA
LTEVRRISHR LRPAMLDVLG LPAALEHLGR EFGDHSGLAF SMRMRGPSIE LPDDVKTVLF
RVTQEALTNI EKHAAAQSVR IRLAFRPSGL RLAILDDGRG FDLAAVQLDP RRGIGLRNMR
ERLASIGGSF RIRSRSGLTE LIADVPEAQL RRLKEA
//
