ID   A2SGA0_METPP            Unreviewed;      1063 AA.
AC   A2SGA0;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   SubName: Full=Putative cation efflux system transmembrane protein {ECO:0000313|EMBL:ABM94589.1};
GN   OrderedLocusNames=Mpe_A1627 {ECO:0000313|EMBL:ABM94589.1};
OS   Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Methylibium.
OX   NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM94589.1, ECO:0000313|Proteomes:UP000000366};
RN   [1] {ECO:0000313|EMBL:ABM94589.1, ECO:0000313|Proteomes:UP000000366}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC   {ECO:0000313|Proteomes:UP000000366};
RX   PubMed=17158667; DOI=10.1128/JB.01259-06;
RA   Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA   Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA   Hristova K.R.;
RT   "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT   proteobacterium Methylibium petroleiphilum PM1.";
RL   J. Bacteriol. 189:1931-1945(2007).
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
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DR   EMBL; CP000555; ABM94589.1; -; Genomic_DNA.
DR   RefSeq; WP_011829226.1; NC_008825.1.
DR   AlphaFoldDB; A2SGA0; -.
DR   STRING; 420662.Mpe_A1627; -.
DR   KEGG; mpt:Mpe_A1627; -.
DR   eggNOG; COG3696; Bacteria.
DR   HOGENOM; CLU_002755_1_2_4; -.
DR   Proteomes; UP000000366; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CusA-like.
DR   NCBIfam; TIGR00914; 2A0601; 1.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF19; CATION EFFLUX SYSTEM PROTEIN CUSA; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW   Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ABM94589.1};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        390..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        446..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..555
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        874..891
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        898..918
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        924..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        982..1003
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1009..1032
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1063 AA;  115007 MW;  68A1F3E90F4E4D03 CRC64;
     MIAELIRWSI VNRFLVLLAT VIVTAWGLWA VQRTPLDALP DLSDVQVIIR TPYPGQAPRI
     VENQVTYPLT TTMLSVPGAK VVRGYSFFGD SFVYVLFDDG TDPYWARSRV LEYLNQVQSR
     LPAAAKPALG PDATGVGWIY QYALVDRSGT MDAGQLRALQ DWFLKYELKT VPNVAEVASV
     GGMVRQYQVL LDPDKLAAYN VPHGAVIDAI RNANQEAGGS VLELGEAEYV VRASGLLATL
     DDFRKIPLSA TDAGVSVRLG DVARIQVGPE MRRGIGELDG EGEATGGVIV MRSGKNALET
     IAAVKTKIAS LQASLPKGVE IVPTYDRSSL IERAVENLSH KLIEEFIVVA LVCVVFLFHL
     RSAFVAIVTL PLGILASFIV MHYQGVNANV MSLGGIAIAI GAMVDAAVVM IENAHKHIEA
     WRHEHPGEDL KGEAQWRVVG DAAVEVGPAL FFSLLIITLS FIPVFTLEAQ EGRLFSPLAY
     TKTYAMAASA GLAVTLVPVL MGYLIRGRIP DERRNPLNRA LIAIYRPLLD GVLAWPKATI
     AVALLLLAST AWPILKIGGE FMPPLDEGDL LYMPTALPGL SAGKAAELLQ QTDRLIKTLP
     EVQSVYGKAG RAETATDPAP MEMFETTIQF KPKDQWRDGM TSDRLVEELD RIVKVPGLSN
     IWVPPIRNRI DMLATGIKSP VGVKVAGTDL AEIDRIASEV EKAVRGVPGV SSALAERLTG
     GRYVDVNINR DTAARYGMNI ADVQSVISTA VGGDNVGETV EGLQRFPINV RYPREVRDSL
     EKLRKLPFVT PRGARIVLSD VAELRISDGP PMLRSENARL AGFVYVDIRG RDLKSAVIDM
     QKVVAEQVKL TPGYSVSWSG QFEFLERATA KLKVVVPFTL GIIVVLLYLT FRRFDEALLI
     LATLPFALIG GFWLLYLLGY NLSVAGAIGF IALAGVAAEF GVIMLLYLKQ AWEARLARGL
     SSDADLMDAI REGAVLRVRP KAMTVAVIIA GLVPIMFGGG TGSEVMQRIA APMVGGMVTA
     PLLSMFVVPA IYRLVRRRRR ASAGEAAAVP GKSSIPTPAP SAA
//