ID A2SIF0_METPP Unreviewed; 732 AA.
AC A2SIF0;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Mpe_A2384 {ECO:0000313|EMBL:ABM95339.1};
OS Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Methylibium.
OX NCBI_TaxID=420662 {ECO:0000313|EMBL:ABM95339.1, ECO:0000313|Proteomes:UP000000366};
RN [1] {ECO:0000313|EMBL:ABM95339.1, ECO:0000313|Proteomes:UP000000366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1232 / LMG 22953 / PM1
RC {ECO:0000313|Proteomes:UP000000366};
RX PubMed=17158667; DOI=10.1128/JB.01259-06;
RA Kane S.R., Chakicherla A.Y., Chain P.S.G., Schmidt R., Shin M.W.,
RA Legler T.C., Scow K.M., Larimer F.W., Lucas S.M., Richardson P.M.,
RA Hristova K.R.;
RT "Whole-genome analysis of the methyl tert-butyl ether-degrading beta-
RT proteobacterium Methylibium petroleiphilum PM1.";
RL J. Bacteriol. 189:1931-1945(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP000555; ABM95339.1; -; Genomic_DNA.
DR AlphaFoldDB; A2SIF0; -.
DR STRING; 420662.Mpe_A2384; -.
DR KEGG; mpt:Mpe_A2384; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_380693_0_0_4; -.
DR Proteomes; UP000000366; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000000366};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 187..271
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 732 AA; 79582 MW; 681FADBA552931D7 CRC64;
MSVVYVEPDR LLDLQMPSGG QPEREHQTVS LAVPRKGHVL STIAEQYGAP MRRAATLLAD
AVSPKAADAV WHRLHARRRV EPGAHQVRSP NDLAAWMAVG AWTAGVVTGR LRENATLGEA
ESWFLGGLAQ TGFVSLVPDS VRVEAEGLLH EIADHKALLD LLPYVLDPHG EGSRMSVMLR
PETAPTRARK KADGVFYTPA DVAGFMAERI VRSLIDDAVP LTVFDPACGS GVFLRAVLTE
LKRRHPGADA FDLACSCLYG ADIDPWAVSA AALVVLVDSF ESVEARGIAP VAAWHALRLN
LVHMDTLRLD PGRAVPHDDP ERIARLACRA ALKAGTLPEV EGEPPPSGPV GFQAVFPEIA
EGAHVIIGNP PYASFGEAAD FLSLSKRFET FQAAPKSTSD MYPLFVEQMT RLTAPDAHGG
AMVLPLSLAC NTSRQFLALR RLLSRTPGHW QFAFFDREPH ALFGEDVKTR NAIALWVRHG
CESDVRISTG PLRKWRGGDR ARMLAGINFT PINADIRLGI PKLEGAMQSE VLAHLVELRY
TLAHAAPHIG RATLGQAMQE SNAKTVFVAA TAYNFLSVFL CPTSHSLGGE DLFTENPLHA
IACPSPEAAL QIFALLSSRL AFWWWHVHGD GFHVSKHVIE TMPVGGMLDC AEHATEMTRL
GALLWNEISV SPIVSRNRGK TSLGFSAVAS PLRSKIDALL VRALGLPSEF THELERFCED
VTRARTLPGT ER
//
