GenomeNet

Database: UniProt
Entry: A2VCU8
LinkDB: A2VCU8
Original site: A2VCU8 
ID   NELL2_XENTR             Reviewed;         814 AA.
AC   A2VCU8;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   16-JAN-2019, entry version 72.
DE   RecName: Full=Protein kinase C-binding protein NELL2;
DE   AltName: Full=NEL-like protein 2;
DE   Flags: Precursor;
GN   Name=nell2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
DR   EMBL; BC128627; AAI28628.1; -; mRNA.
DR   RefSeq; NP_001090754.1; NM_001097285.1.
DR   UniGene; Str.62624; -.
DR   ProteinModelPortal; A2VCU8; -.
DR   SMR; A2VCU8; -.
DR   STRING; 8364.ENSXETP00000032027; -.
DR   PaxDb; A2VCU8; -.
DR   PRIDE; A2VCU8; -.
DR   Ensembl; ENSXETT00000032027; ENSXETP00000032027; ENSXETG00000014625.
DR   GeneID; 100037839; -.
DR   KEGG; xtr:100037839; -.
DR   CTD; 4753; -.
DR   Xenbase; XB-GENE-852641; nell2.
DR   eggNOG; ENOG410IR7C; Eukaryota.
DR   eggNOG; ENOG410XSZA; LUCA.
DR   GeneTree; ENSGT00810000125439; -.
DR   HOGENOM; HOG000217920; -.
DR   HOVERGEN; HBG004805; -.
DR   InParanoid; A2VCU8; -.
DR   OMA; SHHPHTE; -.
DR   OrthoDB; 767046at2759; -.
DR   TreeFam; TF323325; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000014625; Expressed in 13 organ(s), highest expression level in brain.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF07645; EGF_CA; 4.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 3.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    814       Protein kinase C-binding protein NELL2.
FT                                /FTId=PRO_0000354685.
FT   DOMAIN       53    226       Laminin G-like.
FT   DOMAIN      270    329       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      395    437       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      438    479       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      480    520       EGF-like 3; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      521    551       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      553    599       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      600    635       EGF-like 6; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      636    691       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      696    754       VWFC 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   CARBOHYD     51     51       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    223    223       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    296    296       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    515    515       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    613    613       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    633    633       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    399    411       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    405    420       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    422    436       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    442    455       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    449    464       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    466    478       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    484    497       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    491    506       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    508    519       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    523    533       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    527    539       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    541    550       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    557    570       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    564    579       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    581    598       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    604    617       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    611    626       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    628    634       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   814 AA;  90762 MW;  87EB9F240779A9B7 CRC64;
     MEFILGIFCV IFCLRAGAGF GVDPSLQIDI FEDFQLGEAT PGVQQVQGFH NRSKAFLFQD
     TSRSIKASAE TAERIFTKLR NKHEFTILVT LKQAMLNSGV ILSIHHADHR YLELESSGHR
     NEVRLHYRSG SHRSQTEVFP YILADDKWHR FSIAISASHL VLHIDCNKIY ERIVEKTFMD
     VPPGTALWVG QRNNVHGYFK GIMQDLQIVV MPQGFISQCP DLNRTCPTCN DFHGLVQKIM
     ELQDILAKTS AKLSRAEQRM NRLDQCYCER SCTVKGNIYR ELESWMDGCK KCTCTNGTAQ
     CETLTCSVPN CLSGFAPAYV PGKCCKECQP VCMYQGQMYF EGEQEAVQSS SGACVLFQCK
     SNTMQRIESP ECLPLNCPQS QHITLRSGCC KVCKGHDFCS EGHNCVEYSI CKNLNDKAVC
     ICRDGFRALR EDSAYCEDID ECTEGRHYCR ENTVCVNTPG SFMCVCQTGY LKIDDYSCTE
     HNECATNQHS CDENAVCYNT VGGHNCVCQP GYTGNGTVCK AFCTDGCRNG GTCIAPNICA
     CPQGFTGPSC EADIDECTEG FVQCDSRANC INLPGWYHCE CRDGYHDNGM FSLSGESCED
     IDECATGRHS CSNDTVCFNL DGGFDCRCPH GKNCSGDCTH EGKIKHNGQI WVLENDRCSV
     CSCQVGLVMC RRMVCDCENP TVDLFCCPEC DPRLSSQCLH QSGELTYKSG DTWVQNCQQC
     RCLQGEVDCW PLPCPEIDCE FSVVPESECC PRCISDPCQA DIIRNDITKT CVDETNVVRF
     TGSSWIKHGT ECTLCQCKNG HMCCSVDPQC LQEL
//
DBGET integrated database retrieval system