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Database: UniProt
Entry: A2X4M8
LinkDB: A2X4M8
Original site: A2X4M8 
ID   ITPK4_ORYSI             Reviewed;         355 AA.
AC   A2X4M8;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   13-FEB-2019, entry version 65.
DE   RecName: Full=Inositol-tetrakisphosphate 1-kinase 4 {ECO:0000305};
DE            EC=2.7.1.134 {ECO:0000305};
DE   AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase 4 {ECO:0000305};
DE            Short=Inositol-triphosphate 5/6-kinase 4 {ECO:0000305};
DE            Short=Ins(1,3,4)P(3) 5/6-kinase 4 {ECO:0000305};
DE            Short=OsITP5/6K-4 {ECO:0000305};
DE            Short=OsITPK4 {ECO:0000305};
DE            EC=2.7.1.159 {ECO:0000305};
GN   Name=ITPK4; ORFNames=OsI_07149 {ECO:0000312|EMBL:EAY85788.1};
OS   Oryza sativa subsp. indica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39946;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. 93-11;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
RA   Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
RA   Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
RA   Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
RA   Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
RA   Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
RA   Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
RA   Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
RA   Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
RA   Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA   Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA   Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA   Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
RA   Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Kinase that can phosphorylate various inositol
CC       polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 and
CC       participates in phytic acid biosynthesis in developing seeds.
CC       Phytic acid is the primary storage form of phosphorus in cereal
CC       grains and other plant seeds. {ECO:0000250|UniProtKB:Q84Y01}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-
CC         inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:12452, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57539, ChEBI:CHEBI:57733, ChEBI:CHEBI:456216;
CC         EC=2.7.1.134; Evidence={ECO:0000305};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-
CC         inositol 1,3,4,5-tetrakisphosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:13253, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57895, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216;
CC         EC=2.7.1.159; Evidence={ECO:0000305};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-
CC         inositol 1,3,4,6-tetrakisphosphate + ADP + H(+);
CC         Xref=Rhea:RHEA:20940, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57660, ChEBI:CHEBI:58414, ChEBI:CHEBI:456216;
CC         EC=2.7.1.159; Evidence={ECO:0000305};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q13572};
CC       Note=Binds 2 magnesium ions per subunit.
CC       {ECO:0000250|UniProtKB:Q13572};
CC   -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q13572}.
CC   -!- SIMILARITY: Belongs to the ITPK1 family. {ECO:0000305}.
DR   EMBL; CM000127; EAY85788.1; -; Genomic_DNA.
DR   ProteinModelPortal; A2X4M8; -.
DR   SMR; A2X4M8; -.
DR   STRING; 39946.BGIOSGA008174-PA; -.
DR   EnsemblPlants; BGIOSGA008174-TA; BGIOSGA008174-PA; BGIOSGA008174.
DR   Gramene; BGIOSGA008174-TA; BGIOSGA008174-PA; BGIOSGA008174.
DR   eggNOG; ENOG410IHA6; Eukaryota.
DR   eggNOG; ENOG4110KIK; LUCA.
DR   OMA; ENSANRF; -.
DR   Proteomes; UP000007015; Chromosome 2.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0047325; F:inositol tetrakisphosphate 1-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052726; F:inositol-1,3,4-trisphosphate 5-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0052725; F:inositol-1,3,4-trisphosphate 6-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0032957; P:inositol trisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR008656; Inositol_tetrakis-P_1-kinase.
DR   InterPro; IPR040464; InsP(3)kin_ATP-grasp.
DR   PANTHER; PTHR14217; PTHR14217; 1.
DR   Pfam; PF05770; Ins134_P3_kin; 1.
DR   PIRSF; PIRSF038186; ITPK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN         1    355       Inositol-tetrakisphosphate 1-kinase 4.
FT                                /FTId=PRO_0000431876.
FT   DOMAIN      107    318       ATP-grasp. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00409}.
FT   NP_BIND     179    190       ATP. {ECO:0000250|UniProtKB:Q13572}.
FT   METAL       272    272       Magnesium 1.
FT                                {ECO:0000250|UniProtKB:Q13572}.
FT   METAL       289    289       Magnesium 1.
FT                                {ECO:0000250|UniProtKB:Q13572}.
FT   METAL       289    289       Magnesium 2.
FT                                {ECO:0000250|UniProtKB:Q13572}.
FT   METAL       291    291       Magnesium 2.
FT                                {ECO:0000250|UniProtKB:Q13572}.
FT   BINDING      65     65       1D-myo-inositol 1,3,4-trisphosphate.
FT                                {ECO:0000250|UniProtKB:Q9XYQ1}.
FT   BINDING     101    101       ATP. {ECO:0000250|UniProtKB:Q13572}.
FT   BINDING     146    146       ATP. {ECO:0000250|UniProtKB:Q13572}.
FT   BINDING     157    157       1D-myo-inositol 1,3,4-trisphosphate.
FT                                {ECO:0000250|UniProtKB:Q9XYQ1}.
FT   BINDING     190    190       1D-myo-inositol 1,3,4-trisphosphate.
FT                                {ECO:0000250|UniProtKB:Q9XYQ1}.
FT   BINDING     205    205       ATP. {ECO:0000250|UniProtKB:Q13572}.
FT   BINDING     291    291       1D-myo-inositol 1,3,4-trisphosphate.
FT                                {ECO:0000250|UniProtKB:Q9XYQ1}.
SQ   SEQUENCE   355 AA;  38493 MW;  2C2D63FB30627983 CRC64;
     MAPELSSPSS SPRYTVGYAL LPEKVSSVVR PSLVALAADR GVRLVAVDVS RPLAEQGPFD
     LLVHKMYDRG WRAQLEELAA RHPGVPVVVD SPGAIDRLLD RATMLDVVSG LRTPVSVPPQ
     VVVSDAAADA DELLARAALR FPLIAKPLAV DGSAESHDMR LVYRRDGVLP LLRAPLVLQE
     FVNHGGVLFK VYVVGDRATC VRRSSLPDVP ARRLLDLDAE PSVPFANISN QPLPPPDDDG
     GAADDDTPAA GFVDEVARGL RRGLGLHLFN FDMIRERSEE HGDRYFIIDI NYFPGYAKMP
     GYEAALTDFF LEMLRGTRPV PEQLGPGSGL DMEARKLEPG LGIGLRELES GRAQA
//
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