ID A3CRX0_METMJ Unreviewed; 320 AA.
AC A3CRX0;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:ABN56120.1};
DE EC=4.2.1.46 {ECO:0000313|EMBL:ABN56120.1};
GN OrderedLocusNames=Memar_0186 {ECO:0000313|EMBL:ABN56120.1};
OS Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX NCBI_TaxID=368407 {ECO:0000313|EMBL:ABN56120.1, ECO:0000313|Proteomes:UP000002146};
RN [1] {ECO:0000313|EMBL:ABN56120.1, ECO:0000313|Proteomes:UP000002146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35101 / DSM 1498 / JR1
RC {ECO:0000313|Proteomes:UP000002146};
RX PubMed=21304656; DOI=10.4056/sigs.32535;
RA Anderson I.J., Sieprawska-Lupa M., Lapidus A., Nolan M., Copeland A.,
RA Glavina Del Rio T., Tice H., Dalin E., Barry K., Saunders E., Han C.,
RA Brettin T., Detter J.C., Bruce D., Mikhailova N., Pitluck S., Hauser L.,
RA Land M., Lucas S., Richardson P., Whitman W.B., Kyrpides N.C.;
RT "Complete genome sequence of Methanoculleus marisnigri Romesser et al. 1981
RT type strain JR1.";
RL Stand. Genomic Sci. 1:189-196(2009).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CP000562; ABN56120.1; -; Genomic_DNA.
DR RefSeq; WP_011843041.1; NC_009051.1.
DR AlphaFoldDB; A3CRX0; -.
DR STRING; 368407.Memar_0186; -.
DR GeneID; 76730768; -.
DR KEGG; mem:Memar_0186; -.
DR eggNOG; arCOG01371; Archaea.
DR HOGENOM; CLU_007383_1_14_2; -.
DR OrthoDB; 4907at2157; -.
DR Proteomes; UP000002146; Chromosome.
DR GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR CDD; cd05246; dTDP_GD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; TIGR01181; dTDP_gluc_dehyt; 1.
DR PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:ABN56120.1}; NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 4..303
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 320 AA; 35968 MW; 859178B19FFDF78E CRC64;
MRILVTGGLG FIGSNFIRQM LEEHPGDSIV NLDKITYAGN PENLKDIAGD PRYTFVRGDI
CDPGVVGSVF REHPIDAVVH FAAESHVDRS IEDASVFVRT NVLGTHVLLE AALSHGVGRF
IHVSTDEVYG SIKSGSFRET DNLNPSSPYS ASKAASDLLA RSYYITHNLP VIVTRCTNNF
GPYQYPEKLI PLFATNLLEG KKVPVYGTGK NVRDWIHVAD HCRAVDFVLR HGEPGEVYNI
GGDNEKSNLE ITEGILRAVG KDESMVEYVP DRLGHDWRYS LDSSKLRAMG WKPEFDFETA
LRATVQWYTE NEWWWRPLKR
//
