ID A3FPU2_CRYPI Unreviewed; 1017 AA.
AC A3FPU2;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Conserved hypothetical multi-pass transmembrane protein, possible ion transporter {ECO:0000313|EMBL:EAZ51515.1};
GN ORFNames=cgd6_2140 {ECO:0000313|EMBL:EAZ51515.1};
OS Cryptosporidium parvum (strain Iowa II).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Cryptosporidiidae; Cryptosporidium.
OX NCBI_TaxID=353152 {ECO:0000313|EMBL:EAZ51515.1, ECO:0000313|Proteomes:UP000006726};
RN [1] {ECO:0000313|EMBL:EAZ51515.1, ECO:0000313|Proteomes:UP000006726}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Iowa II {ECO:0000313|Proteomes:UP000006726};
RX PubMed=15044751; DOI=10.1126/science.1094786;
RA Abrahamsen M.S., Templeton T.J., Enomoto S., Abrahante J.E., Zhu G.,
RA Lancto C.A., Deng M., Liu C., Widmer G., Tzipori S., Buck G.A., Xu P.,
RA Bankier A.T., Dear P.H., Konfortov B.A., Spriggs H.F., Iyer L.,
RA Anantharaman V., Aravind L., Kapur V.;
RT "Complete genome sequence of the apicomplexan, Cryptosporidium parvum.";
RL Science 304:441-445(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAZ51515.1}.
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DR EMBL; AAEE01000002; EAZ51515.1; -; Genomic_DNA.
DR RefSeq; XP_001388321.1; XM_001388284.1.
DR AlphaFoldDB; A3FPU2; -.
DR STRING; 353152.A3FPU2; -.
DR EnsemblProtists; EAZ51515; EAZ51515; cgd6_2140.
DR GeneID; 3375946; -.
DR KEGG; cpv:cgd6_2140; -.
DR VEuPathDB; CryptoDB:cgd6_2140; -.
DR InParanoid; A3FPU2; -.
DR OMA; CKRSINS; -.
DR OrthoDB; 228442at2759; -.
DR Proteomes; UP000006726; Chromosome 6.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR013099; K_chnl_dom.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF10; SLOWPOKE 2, ISOFORM D; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000006726};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 112..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..186
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
SQ SEQUENCE 1017 AA; 117028 MW; 478CB3E5B5DF1CC1 CRC64;
MSNEFYSNKL FTLKGVELIH WGIHTGYPSF SQLLKNTSEI LSSFIEMCFR QTQTPAYQTG
HIVKSMLWSG VYIWATTKMY RKNNNDPWNF KRIPEIYYFF ESTFLWMLSY DYVIGIFAGA
ITIILTHAGA IFTIESPSEK EYNSLFDYLY YSVVTIGTVG YGDFSPRKRE GRLATIILIT
LTLVLLPHEF QRLKEALNTP PDSIGSFIRK NDTYLCIIGP IPPKLLFITK SLSLQKQRRF
KSIVLVTPIQ ILEYQNIVKI SQQRGYIRLS IKQGFLGSAI NNLVQYSSIV LIYGSEKPIL
HDVICNEGTQ KSDFDALITV MCLTNLLGLK DKFFLIFYSS QVASLSKITG VLGSLSLENL
RIKLLSKCIS NCPGFLPIML HLIIPKNENM LKKLQEPPKN TFFTSNIDRS KITPYEWKCR
WRGLHFKVYT LRFPNSFFGY PIQIFTKYIY KHLGIFLIGV YCPDTNRTYL NPHQYIIGDN
SNIYYEGSNY LGIVLSSSIS LVKKAELLES PKNYTEEFIK KVGRRSCSPS NVFLNRSKKF
KSKEYIENKD QLNIYDCTII SEIHKHCDSN DTDKNIIKNL ININETGKNI QITQHNREFT
NLINYSSSYD DQCLFDQVKN MVLPNHFEET ASNMTNINSK FDICKINSNT VSFSQSNLNF
LPETNTGIPV VSNYLEAISK VFTNREYPIV LIIGWCEQID MLVKLTFSLK PSNFIVLCEK
IIDSSFINEE FFGRIAQISG VGTSEHDLKQ AGVLVASRII IFDSTGNPSN IYKEELINVR
YGKHAIGTWI VVCYLFSKYK KKDNCLVGSQ KMPPLIIDIK ETDIGLLLFQ YSDDWPTRID
GSTYSIPYKN ELDFFYSRQF LSGQFFVDNI IDSLIPFLVP ILDNNPINKS FINQIIYGNP
TSKPFGNVRY YNEKNCSLQM EEIPFVFVNS TFYNLFSQLL KHGRLAIGIY RPIRVDDHQF
NKKQDIKTQK FSPSLGDLES VINENSVKEC FNCETHLIIS CPPPKFKINL GDCVYFL
//
