ID A3GGR4_PICST Unreviewed; 965 AA.
AC A3GGR4;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 16-JUN-2009, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Membrane signaling protein {ECO:0000313|EMBL:EAZ63969.2};
GN ORFNames=PICST_28706 {ECO:0000313|EMBL:EAZ63969.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:EAZ63969.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:EAZ63969.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SYG1 (TC 2.A.94) family.
CC {ECO:0000256|ARBA:ARBA00009665}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAZ63969.2}.
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DR EMBL; AAVQ01000001; EAZ63969.2; -; Genomic_DNA.
DR RefSeq; XP_001387992.2; XM_001387955.1.
DR AlphaFoldDB; A3GGR4; -.
DR STRING; 322104.A3GGR4; -.
DR GeneID; 4851463; -.
DR KEGG; pic:PICST_28706; -.
DR eggNOG; KOG1162; Eukaryota.
DR HOGENOM; CLU_006116_1_1_1; -.
DR InParanoid; A3GGR4; -.
DR OMA; GDMYCSL; -.
DR OrthoDB; 7162at2759; -.
DR Proteomes; UP000002258; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd14475; SPX_SYG1_like; 1.
DR InterPro; IPR004342; EXS_C.
DR InterPro; IPR004331; SPX_dom.
DR PANTHER; PTHR10783:SF103; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1; 1.
DR PANTHER; PTHR10783; XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED; 1.
DR Pfam; PF03124; EXS; 1.
DR Pfam; PF03105; SPX; 1.
DR PROSITE; PS51380; EXS; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 434..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 598..622
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..371
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT DOMAIN 635..829
FT /note="EXS"
FT /evidence="ECO:0000259|PROSITE:PS51380"
FT REGION 38..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 965 AA; 112881 MW; 019A2C5AB9F1E9B3 CRC64;
MKFGESLNEG LVPEWKDQYV DYKAGKKIIK AAGKLKDQYE DELASENEQN EQNDRTPLLN
PQIDEEDHPT YTLDEEPGNS LSEHEREAPS GTSAGAAESA NTSVSFRRPS IFTYSRPATL
KSKDKKEEFE LEKQTFLNWL DDQLQKVDSF YMEKEQDTYE RFLLIQDQLY QLRDHKTSIL
KEKTRHGATF HRADNPDKLY KKVNDFAFHT KSAISALNRL ELPSLPSGVF LDKLRSKQRN
NDIDMSNKME EFNPNDAENR IRNGVTDFNS EFNDESSIDS EATGRDIPNR RQPQTEAQIR
QSKRRDYSTK KQHFGVPYLY ARKQLKDAIL EHYRALSLLK SFKIMNRTAF RKITKKYDKT
MKTSNLLKTY MNKVDNESYF QTSDLLDKLT SHVEELFIAF YDPETTDRKH SLEKLKSIAY
ATNDIRQPTY YRSLFSSGFM LGFGFPLFVL AIYTALRKTL SGEFPEGRFL LQIWGGFFLI
ILVLLLFGIN LAVFDRFKIN YKFIFEFDMS RALNYKQFWL LPSFGFFLLS ILMWFSFHDF
WPDRFAGRDW PWIFFAVSIA IFIWPGDQFY GSSRKWLQIA LWRLLLSGLY PVEFRDFFLG
DILCSLTYTM GNISFFFCLY AHHWSGIDGD SDSNVCGSSK SRLMGFFATL PSIWRFLQCV
RRYMDTGDWF PHLANMLKYA VSALYYCFLS VYRIDRTREN KVIFIIFAFI NSIYSATWDV
VMDWSLLQSG SKNKYLRDNL FFKQPSYYYL AIIADVILRF QWVFYAFFSN QVSQSAVTSF
CIACAEIIRR FIWIFFRMEN EHCTNVILFR ASKDSPLPYN VSARVEKAIK KLVELKYQTQ
SLDRDEDILR RIQFADEGRT PVTHSNLSYT TSSRANVDEE RDVAMSRVPS GTSSLAQLTR
RKSALSSLSE ALNRAHIKDF QRRKTVVAVE YSDEEDDDDV NDLDRTTSFP KSKKTLQSVN
EDDDE
//
