ID   A3J4S4_9FLAO            Unreviewed;       585 AA.
AC   A3J4S4;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:EAZ95661.1};
DE            EC=1.14.16.1 {ECO:0000313|EMBL:EAZ95661.1};
GN   Name=phhA {ECO:0000313|EMBL:EAZ95661.1};
GN   ORFNames=FBBAL38_08165 {ECO:0000313|EMBL:EAZ95661.1};
OS   Flavobacteria bacterium BAL38.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales.
OX   NCBI_TaxID=391598 {ECO:0000313|EMBL:EAZ95661.1, ECO:0000313|Proteomes:UP000003784};
RN   [1] {ECO:0000313|EMBL:EAZ95661.1, ECO:0000313|Proteomes:UP000003784}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BAL38 {ECO:0000313|EMBL:EAZ95661.1,
RC   ECO:0000313|Proteomes:UP000003784};
RA   Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAZ95661.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAXX01000002; EAZ95661.1; -; Genomic_DNA.
DR   AlphaFoldDB; A3J4S4; -.
DR   eggNOG; COG3186; Bacteria.
DR   OrthoDB; 9780502at2; -.
DR   Proteomes; UP000003784; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:UniProtKB-EC.
DR   CDD; cd00361; arom_aa_hydroxylase; 1.
DR   Gene3D; 1.20.58.690; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:EAZ95661.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:EAZ95661.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003784}.
FT   DOMAIN          1..259
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         131
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         136
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         221
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   585 AA;  66032 MW;  8D50CABEDC969BF0 CRC64;
     METHFESNPL IDRLPKHLKQ FIKPQVYEDY TPINQAVWRY VMRKNVSYLS KVAHNSYLEG
     LEKTGLEIDN IPNMYGMNRI LKEIGWAAVA VDGFIPPNAF MEFQAYNVLV IACDIRQLEH
     IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSSRDYEMYE AIRLLSILKE
     AEDTPEEEIK KAEEQVDYLQ KNMGELSEMA QIRNLHWWTV EYGLIGTVEN PKIYGAGLLS
     SIGESAWCMT DNVKKIPYDI SAAYQSFDIT KPQPQLYVTP DFAYLNQVLE EFANTMALRK
     GGPKSVQKLI DSKALGTIEL STGLQISGVF TNVIEHEGKS VYVQTTGKTA LSYREKELVG
     HGTEYHAEGF GSPIGKLKGI NLTIEEMSPR DLRAYDIYEG EQVTLEFEGN ITVKGEIITG
     SRNLQGEILL IKFKNCTVTH NDTVLFQPEW GIYDMAVGKK VISAFSGPAD VNSFDMINHV
     PSSQTIKQKK SQEREELEKL YLSIRNIREN KTATTTLKEA FASVTANHPN DWLLSVEIAE
     LAKKEDNSDL VEKVLNHLEK VKINRPEIAH LINGGLELLF QKAVV
//