ID A3JYQ2_9RHOB Unreviewed; 620 AA.
AC A3JYQ2;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=Glutathione import ATP-binding protein GsiA {ECO:0000256|ARBA:ARBA00041187};
DE EC=7.4.2.10 {ECO:0000256|ARBA:ARBA00039050};
GN ORFNames=SSE37_07353 {ECO:0000313|EMBL:EBA09605.1};
OS Sagittula stellata E-37.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Sagittula.
OX NCBI_TaxID=388399 {ECO:0000313|EMBL:EBA09605.1, ECO:0000313|Proteomes:UP000005713};
RN [1] {ECO:0000313|EMBL:EBA09605.1, ECO:0000313|Proteomes:UP000005713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=E-37 {ECO:0000313|EMBL:EBA09605.1,
RC ECO:0000313|Proteomes:UP000005713};
RA Moran M.A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ABC transporter complex GsiABCD involved in
CC glutathione import. Responsible for energy coupling to the transport
CC system. {ECO:0000256|ARBA:ARBA00037530}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glutathione(out) + H2O = ADP + glutathione(in) + H(+) +
CC phosphate; Xref=Rhea:RHEA:29791, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57925, ChEBI:CHEBI:456216; EC=7.4.2.10;
CC Evidence={ECO:0000256|ARBA:ARBA00036581};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GsiA),
CC two transmembrane proteins (GsiC and GsiD) and a solute-binding protein
CC (GsiB). {ECO:0000256|ARBA:ARBA00011469}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004417}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004417}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Glutathione
CC importer (TC 3.A.1.5.11) family. {ECO:0000256|ARBA:ARBA00038416}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EBA09605.1}.
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DR EMBL; AAYA01000002; EBA09605.1; -; Genomic_DNA.
DR RefSeq; WP_005855688.1; NZ_AAYA01000002.1.
DR AlphaFoldDB; A3JYQ2; -.
DR eggNOG; COG4172; Bacteria.
DR OrthoDB; 9802264at2; -.
DR Proteomes; UP000005713; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0015833; P:peptide transport; IEA:InterPro.
DR CDD; cd03257; ABC_NikE_OppD_transporters; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013563; Oligopep_ABC_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR43776:SF15; GLUTATHIONE IMPORT ATP-BINDING PROTEIN GSIA; 1.
DR PANTHER; PTHR43776; TRANSPORT ATP-BINDING PROTEIN; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF08352; oligo_HPY; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:EBA09605.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005713};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 21..277
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 316..566
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 620 AA; 67950 MW; 6D314FA3AD24745B CRC64;
MLDDTTDTAA TGAAEAQVPI ARIDKLRVEF QTKDGTVVGV EDISFEINPG ETVCVVGESG
SGKSVSSLSL MRLIEYGGGD IAGGKMLFDR REGGVMDLAT ADQSVMRHIR GNEIGMIFQE
PMTALNPVFT VGRQLTEGLR VHRGMSKAQA EARALELLRE VRIPEPERRL KQYPHELSGG
MRQRVVIAMA LACKPRLLIA DEPTTALDVT IQAEILALMD RLKRETGTAV MFITHDMAVV
AQMADRVVVM FRGKKVEEGT VEEIFENPKH AYTKALLAAV PKLGEMTGKD LPEPMRLVGR
TDQNLDPIKG SDEVLLRVEN LVTRFPVKGG FFRRTVANVH ATEDVSFTLN KGRTLSLVGE
SGCGKSTAGR SLLRLVEPLS GKIDLDGTDI MALSQSGLRD ARREMQMIFQ DPFASLNPQL
QLADQVAEPL VNYGIGSGSE IQDKVANLFD RVELPRSFMR RYPHELSGGQ RQRIAIARAL
ALNPKLIVAD EAVSALDVSV QAQVVNLMME LQAELGLGYV FISHDMAVVE RVSHTVGVMY
LGRIVELGPR RAVFEDPQHP YTKALMKAVP IADPRRRKAE KDLNFKPIPS PIHPVGYEAG
PSVYEEVSPG HLVLTSDSGY
//
