ID A3KNE9_XENLA Unreviewed; 79 AA.
AC A3KNE9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Cyclin-dependent kinases regulatory subunit {ECO:0000256|RuleBase:RU311113};
GN Name=cks2.L {ECO:0000313|RefSeq:NP_001106274.1,
GN ECO:0000313|Xenbase:XB-GENE-922093};
GN Synonyms=cks2 {ECO:0000313|RefSeq:NP_001106274.1,
GN ECO:0000313|Xenbase:XB-GENE-922093}, cks2b
GN {ECO:0000313|EMBL:AAI33805.1, ECO:0000313|RefSeq:NP_001106274.1},
GN Xe-p9 {ECO:0000313|RefSeq:NP_001106274.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI33805.1};
RN [1] {ECO:0000313|RefSeq:NP_001106274.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI33805.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAI33805.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001106274.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC kinases and is essential for their biological function.
CC {ECO:0000256|ARBA:ARBA00002449, ECO:0000256|RuleBase:RU311113}.
CC -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC subunits. {ECO:0000256|ARBA:ARBA00011253}.
CC -!- SIMILARITY: Belongs to the CKS family. {ECO:0000256|ARBA:ARBA00007782,
CC ECO:0000256|RuleBase:RU311113}.
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DR EMBL; BC133804; AAI33805.1; -; mRNA.
DR RefSeq; NP_001106274.1; NM_001112803.1.
DR STRING; 8355.A3KNE9; -.
DR PaxDb; 8355-A3KNE9; -.
DR GeneID; 100049119; -.
DR KEGG; xla:100049119; -.
DR AGR; Xenbase:XB-GENE-922093; -.
DR CTD; 100049119; -.
DR Xenbase; XB-GENE-922093; cks2.L.
DR OMA; MHEPEPH; -.
DR OrthoDB; 204504at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 100049119; Expressed in egg cell and 19 other cell types or tissues.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.170.10; Cyclin-dependent kinase, regulatory subunit; 1.
DR InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR PANTHER; PTHR23415:SF49; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 2; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF01111; CKS; 1.
DR PRINTS; PR00296; CYCLINKINASE.
DR SMART; SM01084; CKS; 1.
DR SUPFAM; SSF55637; Cell cycle regulatory proteins; 1.
DR PROSITE; PS00944; CKS_1; 1.
DR PROSITE; PS00945; CKS_2; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU311113};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU311113};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
SQ SEQUENCE 79 AA; 9764 MW; C7A607FE0CBF28FE CRC64;
MSFKNIYYSD KYTDEHYEYR HVVLPKELAK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH
EPEPHILLFR RPLPKEQQK
//
