ID A3KNP8_DANRE Unreviewed; 297 AA.
AC A3KNP8; A0A8M1NGM7;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Transient receptor potential cation channel, subfamily M, member 1b {ECO:0000313|Ensembl:ENSDARP00000135392, ECO:0000313|RefSeq:NP_001103949.1};
DE SubName: Full=Zgc:162329 protein {ECO:0000313|EMBL:AAI33948.1};
GN Name=trpm1b {ECO:0000313|Ensembl:ENSDARP00000135392,
GN ECO:0000313|RefSeq:NP_001103949.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070424-31};
GN Synonyms=zgc:162329 {ECO:0000313|RefSeq:NP_001103949.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI33948.1};
RN [1] {ECO:0000313|EMBL:AAI33948.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAI33948.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001103949.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20333216;
RA Braasch I., Brunet F., Volff J.N., Schartl M.;
RT "Pigmentation pathway evolution after whole-genome duplication in fish.";
RL Genome Biol. Evol. 1:479-493(2009).
RN [3] {ECO:0000313|RefSeq:NP_001103949.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21468032; DOI=10.1038/emboj.2011.106;
RA Rosel T.D., Hung L.H., Medenbach J., Donde K., Starke S., Benes V.,
RA Ratsch G., Bindereif A.;
RT "RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in
RT alternative splicing regulation.";
RL EMBO J. 30:1965-1976(2011).
RN [4] {ECO:0000313|RefSeq:NP_001103949.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23908157; DOI=10.1002/dvdy.24020;
RA Kastenhuber E., Gesemann M., Mickoleit M., Neuhauss S.C.;
RT "Phylogenetic analysis and expression of zebrafish transient receptor
RT potential melastatin family genes.";
RL Dev. Dyn. 242:1236-1249(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000135392, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135392};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000135392}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000135392};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [7] {ECO:0000313|RefSeq:NP_001103949.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [8] {ECO:0000313|RefSeq:NP_001103949.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABZ01083724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01083725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABZ01083726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133947; AAI33948.1; -; mRNA.
DR RefSeq; NP_001103949.1; NM_001110479.1.
DR Ensembl; ENSDART00000157519.2; ENSDARP00000135392.1; ENSDARG00000103476.2.
DR GeneID; 569946; -.
DR KEGG; dre:569946; -.
DR AGR; ZFIN:ZDB-GENE-070424-31; -.
DR CTD; 569946; -.
DR ZFIN; ZDB-GENE-070424-31; trpm1b.
DR HOGENOM; CLU_046430_0_0_1; -.
DR OrthoDB; 201873at2759; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000103476; Expressed in retina and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005262; F:calcium channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR InterPro; IPR041491; TRPM_SLOG.
DR PANTHER; PTHR13800:SF13; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 1; 1.
DR PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR Pfam; PF18139; LSDAT_euk; 1.
PE 2: Evidence at transcript level;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000313|RefSeq:NP_001103949.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00023303}.
FT DOMAIN 2..265
FT /note="TRPM SLOG"
FT /evidence="ECO:0000259|Pfam:PF18139"
SQ SEQUENCE 297 AA; 32670 MW; EBEAB2639CCA5AEF CRC64;
MYIRVSHDTK PDSLLHLMVK EWQLELPTLL ISVHGGLQNF DLQPKLKQVF GKGLIKAAVT
TGAWIFTGGV STGVIRHVGD ALKDHSSKSR GKVCAIGIAP WGILENKEDL IGKDVNKPYQ
AISNPLSKLA VLNNSHSHFI LSDNGTCGKY GAEVKLRRQL EKHISLQKIN TRLGQGVPVV
CLIVEGGPNV ISIALESLRE EPPVPVVVCD GSGRASDIIS FAHKYSEVEG LVNEDAKEQL
LVTIQKTFNY NKMQSGQILL MVLECMKKRE LVSFYSNVRH HSAININILA KLNQLKG
//