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Database: UniProt
Entry: A3KNS9
LinkDB: A3KNS9
Original site: A3KNS9 
ID   ARAID_DANRE             Reviewed;         230 AA.
AC   A3KNS9; Q502E7; Q5RID6;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=All-trans retinoic acid-induced differentiation factor;
DE   AltName: Full=Apoptosis-related protein 3;
DE            Short=APR-3;
DE   Flags: Precursor;
GN   Name=atraid; Synonyms=apr3; ORFNames=si:ch211-101l18.3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA   Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA   Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA   Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA   Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA   Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA   Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA   Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA   Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA   Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA   Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA   Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA   Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA   Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in osteoblast cell differentiation. May play a
CC       role in inducing the cell cycle arrest (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope
CC       {ECO:0000250|UniProtKB:Q6UW56}. Cell membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q6UW56}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH95730.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
DR   EMBL; BX276101; CAI11536.1; -; Genomic_DNA.
DR   EMBL; BC095730; AAH95730.1; ALT_INIT; mRNA.
DR   EMBL; BC133993; AAI33994.1; -; mRNA.
DR   RefSeq; NP_001038238.1; NM_001044773.1.
DR   UniGene; Dr.84372; -.
DR   STRING; 7955.ENSDARP00000063695; -.
DR   PaxDb; A3KNS9; -.
DR   PRIDE; A3KNS9; -.
DR   Ensembl; ENSDART00000063696; ENSDARP00000063695; ENSDARG00000043388.
DR   GeneID; 553468; -.
DR   KEGG; dre:553468; -.
DR   CTD; 51374; -.
DR   ZFIN; ZDB-GENE-040724-177; atraid.
DR   eggNOG; ENOG410IYNU; Eukaryota.
DR   eggNOG; ENOG4111PJW; LUCA.
DR   GeneTree; ENSGT00390000017252; -.
DR   HOGENOM; HOG000010110; -.
DR   HOVERGEN; HBG054041; -.
DR   InParanoid; A3KNS9; -.
DR   OMA; PGGINAW; -.
DR   OrthoDB; 1027431at2759; -.
DR   PhylomeDB; A3KNS9; -.
DR   TreeFam; TF335766; -.
DR   PRO; PR:A3KNS9; -.
DR   Proteomes; UP000000437; Chromosome 20.
DR   Bgee; ENSDARG00000043388; Expressed in 23 organ(s), highest expression level in retina.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:1903363; P:negative regulation of cellular protein catabolic process; ISS:UniProtKB.
DR   GO; GO:0033689; P:negative regulation of osteoblast proliferation; ISS:UniProtKB.
DR   GO; GO:0030501; P:positive regulation of bone mineralization; ISS:UniProtKB.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0010468; P:regulation of gene expression; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PROSITE; PS00022; EGF_1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Differentiation; Disulfide bond;
KW   EGF-like domain; Membrane; Nucleus; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    230       All-trans retinoic acid-induced
FT                                differentiation factor.
FT                                /FTId=PRO_0000360984.
FT   TOPO_DOM     27    200       Extracellular. {ECO:0000255}.
FT   TRANSMEM    201    221       Helical. {ECO:0000255}.
FT   TOPO_DOM    222    230       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN      152    194       EGF-like.
FT   DISULFID    156    172       {ECO:0000250}.
FT   DISULFID    166    182       {ECO:0000250}.
FT   DISULFID    184    193       {ECO:0000250}.
FT   CONFLICT    187    187       N -> H (in Ref. 2; AAI33994).
FT                                {ECO:0000305}.
SQ   SEQUENCE   230 AA;  25580 MW;  7E7774219D87B73E CRC64;
     MTANVTVSSM YLFTVLLLLF NVYVNSQDTD AQLCQMCEGT IRHDSPVWSF CITKGYVKGH
     CCFKNNTSDV DTIIGLDLSN CSISHVEHLY NSSTALIIDL SNNPISNLSD YVFQGFSQLT
     QLLLPSKLEC PGGRASWEKV EVKSITRICE GQKNACNQTV QMPLVCPENS LCSPYGPGFF
     ECSCLNNFHG YKCMRQGEFP LVKVLGILTA STVVVSSVLW FTQRRKVKNT
//
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