ID A3LN85_PICST Unreviewed; 750 AA.
AC A3LN85;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 24-JAN-2024, entry version 97.
DE SubName: Full=Heat shock protein 78, mitochondrial HSP78 {ECO:0000313|EMBL:ABN64287.2};
DE EC=3.6.1.3 {ECO:0000313|EMBL:ABN64287.2};
GN Name=HSP78 {ECO:0000313|EMBL:ABN64287.2};
GN ORFNames=PICST_54293 {ECO:0000313|EMBL:ABN64287.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN64287.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN64287.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|RuleBase:RU004432}.
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DR EMBL; CP000496; ABN64287.2; -; Genomic_DNA.
DR RefSeq; XP_001382316.2; XM_001382279.1.
DR AlphaFoldDB; A3LN85; -.
DR STRING; 322104.A3LN85; -.
DR GeneID; 4837648; -.
DR KEGG; pic:PICST_54293; -.
DR eggNOG; KOG1051; Eukaryota.
DR HOGENOM; CLU_005070_4_0_1; -.
DR InParanoid; A3LN85; -.
DR OMA; SKMMQGE; -.
DR OrthoDB; 35211at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR028299; ClpA/B_CS2.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF176; HEAT SHOCK PROTEIN 78, MITOCHONDRIAL; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS00871; CLPAB_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004432};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|RuleBase:RU004432};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:ABN64287.2};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004432};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Stress response {ECO:0000313|EMBL:ABN64287.2}.
FT DOMAIN 67..212
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 468..609
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 641..730
FT /note="Clp ATPase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01086"
FT COILED 281..361
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 750 AA; 84595 MW; BC25CB3B3D870FFD CRC64;
MITQKRLFHS TIPKKLQMQQ NEESDNRPAL EKFGSDLTQM AKDGKLDPVI GRDEEIRRTI
QILSRRTKNN PVLIGNAGTG KTAIMEGLAQ RILKGEVPDS MKDKKIITLD LAGIISGSKF
RGDFESKLKS ILKEVEEQHG KVILFVDELH LLMGLGKAEG SIDASNLLKP ALARGMLSLC
GATTIEEYRK YVEKDAALAR RFSPVLVNEP TVQDTISILR GLKERYEVHH GVRITDGALV
TAALYSNRYI TDRFLPDKAI DLVDEASSTL RLQHESKPDA IAQLDRDIMT IEIELESLRK
EEDQLSKDRR SKLEEELKVK KAELAEFTEQ WETERRSIQD VKSAKTELEQ SKFDLEQYQR
DGNYAKASEL QYATIPELEE KLKSLTEKES ANQSSNLLHD SVTSDDIASV ISKMTGIPVN
NLLKGEKDKL LDMEIILKQK VVGQDEAIHA VSDAVRLQRA GLTSDKRPIA SFMFLGPTGT
GKTELTKTLA EFIFNDTSSV IRFDMSEFQE RHSVSRLIGS PPGYVGYEDS GELTEAVRRK
PYSVVLFDEF EKAHKDVSKL LLQVLDEGSL TDSHGKHIDF RNTIIVMTSN IGQEILLADQ
DAHEDGSISE GVKREITEVL KHYYPPEFLN RLDEVLIFNR LSKSSLKNIL DIRLREISER
LDDKRIRLEL TEEAKTLICD LGYDPIYGAR PLNRVLQKQL LNPLALLLIK GQVKETETVS
IEAKSGKIFV RPNHDENIYD ENGEKVGGEE
//