ID A3LNV7_PICST Unreviewed; 621 AA.
AC A3LNV7;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=General amino acid permease {ECO:0000313|EMBL:ABN64932.2};
GN Name=GAP1.7 {ECO:0000313|EMBL:ABN64932.2};
GN ORFNames=PICST_41966 {ECO:0000313|EMBL:ABN64932.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN64932.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN64932.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. YAT (TC 2.A.3.10) family. {ECO:0000256|ARBA:ARBA00006983}.
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DR EMBL; CP000496; ABN64932.2; -; Genomic_DNA.
DR RefSeq; XP_001382961.2; XM_001382924.1.
DR AlphaFoldDB; A3LNV7; -.
DR STRING; 322104.A3LNV7; -.
DR GeneID; 4836951; -.
DR KEGG; pic:PICST_41966; -.
DR eggNOG; KOG1286; Eukaryota.
DR HOGENOM; CLU_007946_12_0_1; -.
DR InParanoid; A3LNV7; -.
DR OMA; LQFWAAL; -.
DR OrthoDB; 2004603at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IEA:UniProt.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR PANTHER; PTHR43341; AMINO ACID PERMEASE; 1.
DR PANTHER; PTHR43341:SF1; GENERAL AMINO-ACID PERMEASE GAP1; 1.
DR Pfam; PF00324; AA_permease; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 100..567
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
SQ SEQUENCE 621 AA; 68867 MW; 085E52F92D090BC7 CRC64;
MVSSLASGQS SDTGSEYSEY SVYSRSYHPR DLFYDFIDSF KPFDYSVLPP IYNTEDTLVS
DKSVLHPNHP QFDYSHLTEL ERAALVTATS PLSKHLKTRH LTLISLGGAI GTGLFIGSAS
SLSHAGPLGM LLVWIFIGSI TFTTMSSLSE LATAFPIAGS FVTFTTLFID ASCGFAIAWN
YALQWLVTMP LELVAVSMTF SYWNTDVHPA VYVAIFYVVI VVINLFGVKG YGEAESLFSI
IKIIAVIGFN ILSIIIVTGG VPGQPYIGGK YWHKPEGGLF NTVEPFKQCC YIIANASFAY
AGVEIFALAA VESKQPKKSI NSARKQIFYR ILVFYICSLV MIGLLVPYTD ERLLGTNTKA
GNIGVDINTS PFVIAIKNAN IRALPTIMNI VIIITVVSVG NASVYGSSRA LCALGALRQG
PSILNFIDRR GRPMAGLLVQ FAFGLLAFLV AIPGPSVTTQ IFNWLLSLSG LSILFTYLSI
NICHLRFRRA LNVRARLPQD ELVYTSPVWV SWYAIICIIT VLGLQFWAAL FPPGNHAADW
ESFLTIYLGL PVLILFYICH KIYAKIFLKV PLTKFWLTAE EIDIDTGRRQ IDMEALKQEI
AEERLSFQSK PLYYKVFRFF C
//
