ID A3LPM9_PICST Unreviewed; 327 AA.
AC A3LPM9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Nitrilase, arylacetone-specific (Arylacetonitrilase) {ECO:0000313|EMBL:ABN65068.1};
GN Name=NRL1 {ECO:0000313|EMBL:ABN65068.1};
GN ORFNames=PICST_30010 {ECO:0000313|EMBL:ABN65068.1};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN65068.1, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN65068.1, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.
CC Nitrilase family. {ECO:0000256|ARBA:ARBA00008129}.
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DR EMBL; CP000496; ABN65068.1; -; Genomic_DNA.
DR RefSeq; XP_001383097.1; XM_001383060.1.
DR AlphaFoldDB; A3LPM9; -.
DR STRING; 322104.A3LPM9; -.
DR GeneID; 4837424; -.
DR KEGG; pic:PICST_30010; -.
DR eggNOG; KOG0805; Eukaryota.
DR HOGENOM; CLU_030130_6_0_1; -.
DR InParanoid; A3LPM9; -.
DR OMA; GYPCWIW; -.
DR OrthoDB; 2785533at2759; -.
DR Proteomes; UP000002258; Chromosome 2.
DR GO; GO:0000257; F:nitrilase activity; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR CDD; cd07564; nitrilases_CHs; 1.
DR Gene3D; 3.60.110.10; Carbon-nitrogen hydrolase; 1.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR000132; Nitrilase/CN_hydratase_CS.
DR InterPro; IPR044149; Nitrilases_CHs.
DR PANTHER; PTHR46044:SF1; CN HYDROLASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46044; NITRILASE; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR SUPFAM; SSF56317; Carbon-nitrogen hydrolase; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
DR PROSITE; PS00920; NITRIL_CHT_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT DOMAIN 9..271
FT /note="CN hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS50263"
FT ACT_SITE 49
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10139"
SQ SEQUENCE 327 AA; 36308 MW; 6D71825EF899459B CRC64;
MSASVYPKLK VAAVQAAPVY LNLEATIAKS VKLIEEAAAN GAKLVAFPEA FVPGYPWFAF
IGHPEYTRKW YHKLYKNALE IPSPAIQKIS NAARDNDIFV CISGSEKDNG SLFLCQLWFD
NKGNLIGKHR KMRASVAERL VWGDGCGSLL PVMKTEIGNL GGLMCWEHQV PLDLAAMNNQ
NEQIHVAAWP GYFDDEISSR YYAISTQSFV VMTSSIYSEE MKQLICEDAE QRKYFDSFKS
GHTCIYGPDG EPVSEMIPAE TEGIAYADID IARTIDFKYY IDPAGHYSNK SLTATHNVSD
TRPIKQIGSS PSQFIGHDDL NRVDVAA
//
