ID A3LS01_PICST Unreviewed; 523 AA.
AC A3LS01;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=N-alkane inducible cytochrome P-450 {ECO:0000313|EMBL:ABN65477.2};
DE EC=1.14.14.1 {ECO:0000313|EMBL:ABN65477.2};
GN Name=ALK2 {ECO:0000313|EMBL:ABN65477.2};
GN ORFNames=PICST_35590 {ECO:0000313|EMBL:ABN65477.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN65477.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN65477.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602402-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; CP000497; ABN65477.2; -; Genomic_DNA.
DR RefSeq; XP_001383506.2; XM_001383469.1.
DR AlphaFoldDB; A3LS01; -.
DR STRING; 322104.A3LS01; -.
DR GeneID; 4838296; -.
DR KEGG; pic:PICST_35590; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_27_0_1; -.
DR InParanoid; A3LS01; -.
DR OMA; VTYKTMF; -.
DR OrthoDB; 4950799at2759; -.
DR Proteomes; UP000002258; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR CDD; cd11063; CYP52; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002974; Cyt_P450_E_CYP52_ascomycetes.
DR InterPro; IPR047146; Cyt_P450_E_CYP52_fungi.
DR InterPro; IPR002402; Cyt_P450_E_grp-II.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24287; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR PANTHER; PTHR24287:SF1; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00464; EP450II.
DR PRINTS; PR01239; EP450IICYP52.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRSR:PIRSR602402-1, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|PIRSR:PIRSR602402-1, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602402-1,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461,
KW ECO:0000313|EMBL:ABN65477.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT BINDING 469
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602402-1"
SQ SEQUENCE 523 AA; 59971 MW; 5316DA57285D3FDA CRC64;
MANFIEFVTT NWYIIIPALL VLHKVFDLLY VQYLYRKLGA KPCTNQTDDH AFGIRAGFEM
LKKKNEGTVV DFGAERFESR IDPKIPTFSM RLFLIPIVLT RDPENIKALL ATQFNEFVLG
SRFEQLAPLL GKGIFTLDGE GWKHSRAMLR PQFAKEQVAH VQSLEPHIQA LAKHVRNAKG
KSFDIQELFH RLTVDSATEF LFGQSVESLR DESVGMADEA TDFAGKSTFA ASFTIAQNWL
ANRAVAQKFY FLINPKEMRD SIKDVHRFVD YYVQVALDTP QDELDKKSKD GYIFLYELVK
QTRDPYVLRS QLLNVLLAGR DTTAGLLSFA FFELARRPDI WSKLKDEIYE NFGSGENSKV
DEITFESLKR CEYLKAFLNE TLRLYPSVPV NFRVATKDTT LPRGGGKDGS EPILVRKGQS
VFYSVYATHR SEAYYGKDRH VFRPERWFEP SARKLGWAYL PFNGGPRICL GQQFALTEAS
YVVARLIQLF PNIENYEPEE VYPPFKNSQL TMNLLNGLHI GLY
//
