ID   A3LSA5_PICST            Unreviewed;       670 AA.
AC   A3LSA5;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=RNA-directed DNA polymerase {ECO:0000313|EMBL:ABN65869.2};
GN   Name=POL5.4 {ECO:0000313|EMBL:ABN65869.2};
GN   ORFNames=PICST_30986 {ECO:0000313|EMBL:ABN65869.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN65869.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN65869.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
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DR   EMBL; CP000497; ABN65869.2; -; Genomic_DNA.
DR   RefSeq; XP_001383898.2; XM_001383861.1.
DR   AlphaFoldDB; A3LSA5; -.
DR   STRING; 322104.A3LSA5; -.
DR   GeneID; 4837928; -.
DR   KEGG; pic:PICST_30986; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   HOGENOM; CLU_409982_0_0_1; -.
DR   InParanoid; A3LSA5; -.
DR   OrthoDB; 2056154at2759; -.
DR   Proteomes; UP000002258; Chromosome 3.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR035179; DUF5314.
DR   InterPro; IPR001878; Znf_CCHC.
DR   PANTHER; PTHR42648:SF18; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR42648; TRANSPOSASE, PUTATIVE-RELATED; 1.
DR   Pfam; PF17241; Retrotran_gag_4; 1.
DR   PROSITE; PS50158; ZF_CCHC; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:ABN65869.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:ABN65869.2};
KW   Transferase {ECO:0000313|EMBL:ABN65869.2};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00047};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00047}.
FT   DOMAIN          235..249
FT                   /note="CCHC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50158"
FT   REGION          545..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..600
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..664
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   670 AA;  73991 MW;  C06CBF11EECAA5F1 CRC64;
     MNASEFQQVM SRHSKFNYSI SFPSEQLLAS KNNFPLWKTR MDQLFEPIGK EFVAYLLPST
     NVDTGYTSED RSAFNSYIEF VLSKTVTEDV RVTLSGESVT GRARWLRLLT LYGTMNHRDV
     VKYVKVLLTM ILNPSLKSKA VKPAIDSLYS FTESYTLDEI KGIQLLATSS APNLIQNYFH
     SGSESLTYDD VFQFLAEYEE NTTEASTAPS VLAATFSTDS RRPSVDANDP LWNTKCYNCG
     GRGHRRDVCC SPIRVGKYTG WSTNTSKKRS FNDNERKKQY KSGATANVAV NESAFVLTTT
     TGSTTSHSSE FIFDSGASIH ICHDRSLFWT FQPESGSFVS CAGGVRLPVL GRGSIKFRSA
     DETIVLQEVC YVPECTKNLI SVHAAVRVSG SPLTTKVDGI YHPRIGRFGV YRDDLGLSVL
     DMKPIPPLVS VLSVLHNRLG HPHQAIEQQV LRDNYSLADI EKIGDVTKSC ASCSEYKKTR
     SIPKVSHKSD TTTPLQILHS DVSGPHNTPG ISSESYFCVL VDDYSKFNSN QVSFDESIYP
     FENSPDHAPT TSASTIPMGV SGVPRFSSDV ATTSRAEHIS SDEHETSSSD HSRAQSPDMH
     REDSPATPVS ISHNLQPLHS SPAASLSSYD STDSELARMP SNLLASDSTG EDWKQEKESA
     INEDDKESEI
//