GenomeNet

Database: UniProt
Entry: A3LV40
LinkDB: A3LV40
Original site: A3LV40 
ID   DBP9_PICST              Reviewed;         581 AA.
AC   A3LV40;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   16-OCT-2019, entry version 74.
DE   RecName: Full=ATP-dependent RNA helicase DBP9;
DE            EC=3.6.4.13;
GN   Name=DBP9; ORFNames=PICST_84074;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 /
OS   NRRL Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
OC   Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-
RT   fermenting yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9
CC       subfamily. {ECO:0000305}.
DR   EMBL; CP000499; ABN66707.1; -; Genomic_DNA.
DR   RefSeq; XP_001384736.1; XM_001384699.1.
DR   SMR; A3LV40; -.
DR   STRING; 4924.XP_001384736.1; -.
DR   PRIDE; A3LV40; -.
DR   EnsemblFungi; ABN66707; ABN66707; PICST_84074.
DR   GeneID; 4839681; -.
DR   KEGG; pic:PICST_84074; -.
DR   eggNOG; KOG0346; Eukaryota.
DR   eggNOG; ENOG410XR15; LUCA.
DR   HOGENOM; HOG000253015; -.
DR   InParanoid; A3LV40; -.
DR   KO; K14810; -.
DR   OMA; RYRAQDC; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    581       ATP-dependent RNA helicase DBP9.
FT                                /FTId=PRO_0000285156.
FT   DOMAIN       47    231       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      260    461       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      60     67       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        15     43       Q motif.
FT   MOTIF       177    180       DEAD box.
SQ   SEQUENCE   581 AA;  66365 MW;  C93061B7ADAD617A CRC64;
     MSTTSASEAY VDDNSSWDSF HLDARLVQAI DQLGFEHPTL IQASAIPLAL EEKRDIIAKA
     STGSGKTGAY VIPIIHNLLT DAEVESGNHH IKSIILVPTR ELSNQVLQFV EKLLVYSNNR
     INAINLSANL SDQVVNSLLM NKPEIIISTP AKLIQVLEKN ANKDLIDLST VRNLTIDEVD
     LVLSYGYLED LQKLETYLPI KKNLQTFLMS ATVNDDLNDL KTRFCSRPAI LKLNDEESAQ
     NKLIQYYART TEFDKFLLAY VIFKLNLIKG KTLVFVNNID RGYRLKLFLE QFGIRCCILN
     SELPINSRLH IVEEYNKNVY NLLIATDETN DFTVEKDEQQ QEESQDKKAS SAKTKQSKKS
     KKQKKDTEYG VSRGVDFRNV ACVLNFDLPT TSKAYIHRIG RTARAGKAGM ALSFVLPIKE
     VGKHKTASLS TAKKDEKILR RIVKQQSKNG FEIKPYQFDM KQVEGFRYRS EDAFRAVTQT
     AIREARIKEL KNELINSDKL KRFFEENPQD LASLRHDKEL HPTRVQSHLK RVPDYLLPES
     ARQDPKKIGF VPFHKNKVHK NRKKKPTGRK ADPLKSFKNR K
//
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