ID A3LW54_PICST Unreviewed; 661 AA.
AC A3LW54;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 24-JAN-2024, entry version 78.
DE RecName: Full=DNA-binding protein RAP1 {ECO:0000256|RuleBase:RU367107};
GN Name=RAP1 {ECO:0000313|EMBL:ABN66909.2};
GN ORFNames=PICST_67919 {ECO:0000313|EMBL:ABN66909.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN66909.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN66909.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Involved in the regulation of telomere length, clustering and
CC has a specific role in telomere position effect (TPE).
CC {ECO:0000256|RuleBase:RU367107}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU367107}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367107}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU367107}.
CC -!- SIMILARITY: Belongs to the RAP1 family. {ECO:0000256|ARBA:ARBA00010467,
CC ECO:0000256|RuleBase:RU367107}.
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DR EMBL; CP000499; ABN66909.2; -; Genomic_DNA.
DR RefSeq; XP_001384938.2; XM_001384901.1.
DR AlphaFoldDB; A3LW54; -.
DR STRING; 322104.A3LW54; -.
DR GeneID; 4839646; -.
DR KEGG; pic:PICST_67919; -.
DR eggNOG; ENOG502S85C; Eukaryota.
DR HOGENOM; CLU_507258_0_0_1; -.
DR InParanoid; A3LW54; -.
DR OMA; TSHKFFE; -.
DR OrthoDB; 1406561at2759; -.
DR Proteomes; UP000002258; Chromosome 5.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; IEA:UniProtKB-UniRule.
DR CDD; cd11655; rap1_myb-like; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR021661; Rap1_C.
DR InterPro; IPR015280; Rap1_DNA-bd.
DR InterPro; IPR039595; TE2IP/Rap1.
DR PANTHER; PTHR16466; TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR16466:SF6; TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF09197; Rap1-DNA-bind; 1.
DR Pfam; PF11626; Rap1_C; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU367107};
KW DNA-binding {ECO:0000313|EMBL:ABN66909.2};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367107};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU367107};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 44..120
FT /note="BRCT"
FT /evidence="ECO:0000259|Pfam:PF16589"
FT DOMAIN 285..401
FT /note="Rap1 DNA-binding"
FT /evidence="ECO:0000259|Pfam:PF09197"
FT DOMAIN 567..659
FT /note="TRF2-interacting telomeric protein/Rap1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11626"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 75288 MW; A058A77FDC5B24D9 CRC64;
MTFSTLHFEG ENTPRRTDRN LPLSMNSPQR SPYNSRLGLE KSTLFTNREG RSIRFYMEYS
EPRRLHYKAL IETHGGVLLD HSVTDCFWLS TNPLTGRRSY RVQYIDDCVR LVTLQDIRIY
SHPDFNIDTN LLHRGAGDTT SGMEMDPTSV AAAVVYGDAQ PNPNLSSAAD LPSDFALATA
STSLSPGTAP KVRTHNRFTP QKDAFILEEV RKHPRARHSH EFFRNLAKNE ILKGHTGNSV
RSRFRKHLEA DLQYVYQQES DGNPSKDAHG NYIPTKELPQ TLKNKYTAED DYYLCTEAKK
YILAKESAKD GGEGRGSGKL PELKVLLPYS FFSNLCRPDR GGQDEVADSE NNPDKRNKKH
IGQRHTLHSW RDRYRKFVGD GTIEKYIKSY EASENPKPLE RRGVINSSSL NNMTGELREI
VGSNARNREE RALDEEIGQT KSSLIGVPDL NMSAGDVLES LEPIERPTMR EIEEDEEIIE
DIEVDDIEDI EDFQDASTQL SSIQANFEDA VNPGSQDSQS VMKYIGKGVK FEDLFTDPSV
LNYDLVSKLN TALRSISDDV QELAECLEEL GFKQALVEHL LYSTCCDKTR LFFLFRHIYN
NLQDNLVSDG HIPVYELLQP PDEGGFWTKE QDDLLQAGRD DALEVQNKRQ IRTRREFLNK
L
//
