ID   A3LX49_PICST            Unreviewed;      1549 AA.
AC   A3LX49;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 2.
DT   24-JAN-2024, entry version 67.
DE   SubName: Full=Anaphase-promoting complex (APC), subunit 1 (Meiotic check point regulator/Tsg24) {ECO:0000313|EMBL:ABN67736.2};
GN   Name=APC1 {ECO:0000313|EMBL:ABN67736.2};
GN   ORFNames=PICST_62242 {ECO:0000313|EMBL:ABN67736.2};
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN67736.2, ECO:0000313|Proteomes:UP000002258};
RN   [1] {ECO:0000313|EMBL:ABN67736.2, ECO:0000313|Proteomes:UP000002258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC   {ECO:0000313|Proteomes:UP000002258};
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- SIMILARITY: Belongs to the APC1 family.
CC       {ECO:0000256|ARBA:ARBA00010547}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000500; ABN67736.2; -; Genomic_DNA.
DR   RefSeq; XP_001385765.2; XM_001385728.1.
DR   STRING; 322104.A3LX49; -.
DR   GeneID; 4840089; -.
DR   KEGG; pic:PICST_62242; -.
DR   eggNOG; KOG1858; Eukaryota.
DR   HOGENOM; CLU_000746_0_0_1; -.
DR   InParanoid; A3LX49; -.
DR   OMA; LEEWHVY; -.
DR   OrthoDB; 180933at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR024990; Apc1.
DR   InterPro; IPR049255; Apc1_N.
DR   InterPro; IPR011989; ARM-like.
DR   PANTHER; PTHR12827:SF3; ANAPHASE-PROMOTING COMPLEX SUBUNIT 1; 1.
DR   PANTHER; PTHR12827; MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER; 1.
DR   Pfam; PF12859; ANAPC1; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT   DOMAIN          39..134
FT                   /note="Anaphase-promoting complex subunit 1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12859"
SQ   SEQUENCE   1549 AA;  173395 MW;  8CAF7E0905BE01F2 CRC64;
     MSEKQSQVLS SPALSLKDEL QVPFSTSPYS IQLFSHYRQL LTSTREVIIL VGSSVSKKLA
     FEEDIVTATF TSFNSPDREA SNSSAECLVV CFRKAANIYY SDGRNYVVSF PFAVKNAFPF
     ESGLVLERDV NSAELSNTQE SIQLSQLGGA KFLTLVDPIG DFRIIATSST SIVSPNEVLL
     SFPRQGLNKT SSLCATFNPQ ERNVIIYSIR ASHRGTKILD SGTKYSRRNY SLLSTPNPSR
     VLEEEGHFDA SVGSSGVNQN VLSLNMEKKR TSTLLADISS IARMGTENNF PDNTKRKSHV
     AHEVPILRRD MILTRTDVLP TNTDKAHMQV FGINFEEQEA IVVVNKLKKE ARVYLYKHHS
     NHFHHCYQIT CKECIPLNSR KMEGFVIALK EDGSIILVNP FVDVSSQKIY LKSKFPNVDG
     LQSSFEENLA IKYKDGNVGT IRLLLQPNNE FVANCLHSFK YLSGSKVTET IWMLWRSALA
     LDESKDEWNA LVIALLTLFF PFQDGIEQCT PNEITNLLPS AKRLSECLDS KVNYGDLASY
     IALSLHLLRE EARLDCTSKS CLNKLGVLLA QFTVWMGWPE SWTKYYLIDF SSIDKSVRFL
     SLLMLDSAPN LFESLASLFT GKIIRYLTFS QLSEESDSVD SLITPRTHCI LKLFEILVSP
     NFGPTAVVDM MCEYGITRGE LETYPPGISI LLKEAISLCQ ENPSFAWTNK TLELVGRKDL
     TMFLSRNSNP RSFTGSKVEV KSISSILSNV LTKYESISPW DGQSEADRIG LTKLIFDYDR
     RYYEITTLLH QTKTQTATLL AEEGISEYDL VLQQRNLAAL VALRTLTIPL GRAALFYAGR
     KPLLTEKFPV PKFNLNTLIA PTMTNIILSD GSIPAKISEW GYFHNGVSSG LSISREAKGI
     TGSWIIFNKP PELNTQHAGF LLGLGLNGHL KKLEEWHIYN YLGPKHPLTS VGLLIGMAAS
     IRGSMDNKLT KVLSVHAVAL LPQGANDLNV PIMVQTAGLI GIGLLYLESQ HRRMSEILLS
     QITSSVSQND TEQIHEGYRL AAGISLGLVN LGKGNDLSGL NDTHVVDRLS SLATSMKDYQ
     PVQELDKSCC GAIMALGFIY IKTENATVAN KLKVPNTEQM LDYIRPDLLL LRSIAKNLIL
     WNDIGKSVEW VQSEVPSVLF EKYGKGHIQV LDSDQLGFFN ILGGSCLSMA VKYASSHDST
     VRNTLLHYLD LMMRISSFNT NNYDQKIAHQ CAGKIRNLIA LSLSVVMAGS GDLETFRRLR
     ILHDDTNKEM GYGNYMAINT ALGFLFLGGG QYAFGNSNFA IACLITSLYP IYPNENSEVD
     VHLQALRHFW ALSVEPRCLI IRDVNSHNPL KIPVSISLKN GEVKEALSPC LLPPLDEILT
     IQTRSRDYFN AQIDFELNSE YLEIFKKSLT VFVYKRRNFK LLSPSIGSLI KNENKSLQIE
     NGEIKISEDV STLLKLEAMG HIDDYEKQVL LYECSENDDS HAYSTELSIF NIIDNKIDLA
     RMANSPQSME DLWNLKLLFS YSDRLMNSEL HYVSVEFIDQ LKQEVWAIS
//