ID ERB1_PICST Reviewed; 809 AA.
AC A3LXF0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 3.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000255|HAMAP-Rule:MF_03027};
DE AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000255|HAMAP-Rule:MF_03027};
GN Name=ERB1 {ECO:0000255|HAMAP-Rule:MF_03027}; ORFNames=PICST_32792;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03027}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03027}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABN67445.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000500; ABN67445.2; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001385474.2; XM_001385437.1.
DR AlphaFoldDB; A3LXF0; -.
DR SMR; A3LXF0; -.
DR STRING; 322104.A3LXF0; -.
DR GeneID; 4840028; -.
DR KEGG; pic:PICST_32792; -.
DR eggNOG; KOG0650; Eukaryota.
DR HOGENOM; CLU_011390_0_1_1; -.
DR InParanoid; A3LXF0; -.
DR OrthoDB; 5472008at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03027; BOP1; 1.
DR InterPro; IPR028598; BOP1/Erb1.
DR InterPro; IPR012953; BOP1_N_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17605:SF0; RIBOSOME BIOGENESIS PROTEIN BOP1; 1.
DR PANTHER; PTHR17605; RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN; 1.
DR Pfam; PF08145; BOP1NT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM01035; BOP1NT; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..809
FT /note="Ribosome biogenesis protein ERB1"
FT /id="PRO_0000370439"
FT REPEAT 435..474
FT /note="WD 1"
FT REPEAT 483..523
FT /note="WD 2"
FT REPEAT 593..635
FT /note="WD 3"
FT REPEAT 638..676
FT /note="WD 4"
FT REPEAT 679..718
FT /note="WD 5"
FT REPEAT 722..762
FT /note="WD 6"
FT REPEAT 778..809
FT /note="WD 7"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..383
FT /note="Required for interaction with NOP7"
FT /evidence="ECO:0000250"
FT REGION 383..419
FT /note="Required for interaction with YTM1"
FT /evidence="ECO:0000250"
FT REGION 545..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..93
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 809 AA; 92228 MW; ADB10BB3CA5143C4 CRC64;
MSKSSKVGMT DVSVPKSAVL KKRNQREVEA EVDESSEEEF EMDGLLDAEA SEDDEEDEEN
SEDDEEEDSD KELNELLGEE EDPSDYDSEN FSDEPQESDT RSITDAISGV KIRSLSDISS
QDKQEFHTKY SDGSERIIKP EIEPVYDSDD SDAENFNTIG DIPLSAYDEM PHLGYDINGK
RIMRPAKGSA LDQLLESIDL PQGWTGLLDQ NTGSSLNLTD EELELIRKIQ QQENTDANID
PYEATIEWFT SKVEVMPLTA VPEPKRRFVP SKHEAKRVMK IVRAIREGRI IPPSKVKEQI
EEERLNYDLW NDDDIAVEDH IMNLRAPKLP PPTNEESYNP PEEYLLTEEE KKQWESLDPA
DRERNFLPQK FGALRKVPGY QESVRERFER CLDLYLAPRV RHNKLNIDPE SLIPELPSPK
DLRPFPIRCS TVYQGHTDKI RTISIDPQGL WLATGSDDGS VRIWEILTGR QVFNVQLINK
EINDEDHIES LEWNPDSQTG ILAVCAGENI YLVVPPIFGF DIENMGRLRI ESGWGYDTFG
NKTKEEKFKN DEGNEDEDDE DDSATSTAVK KDVARWFPPN QEQTKLGISA IIQCRKTVKK
VSWHRKGDYF VTVSPDSKNT AVLIHQLSKH LSQSPFKKSK GIIMDAKFHP FKPQLFVASQ
RQVRIYDLAQ QVLVKKLMPG VRLLSTIDIH PRGDNLLASS YDKRVLWHDL DLSATPYKTL
RYHEKAVRSI KFHKGNLPLF ASASDDGNIH IFHGTVYDDL MTNPLLVPLK KLTGHKIVNS
IGILDLIWHP KEAWLFSAGA DGTARLWTT
//
