ID A3LY48_PICST Unreviewed; 709 AA.
AC A3LY48;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN ORFNames=PICST_68166 {ECO:0000313|EMBL:ABN67918.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN67918.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN67918.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC {ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604, ECO:0000256|PIRNR:PIRNR028977}.
CC -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC {ECO:0000256|ARBA:ARBA00007797, ECO:0000256|PIRNR:PIRNR028977}.
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DR EMBL; CP000500; ABN67918.2; -; Genomic_DNA.
DR RefSeq; XP_001385947.2; XM_001385910.1.
DR AlphaFoldDB; A3LY48; -.
DR STRING; 322104.A3LY48; -.
DR GeneID; 4839805; -.
DR KEGG; pic:PICST_68166; -.
DR eggNOG; KOG2153; Eukaryota.
DR HOGENOM; CLU_012441_3_1_1; -.
DR InParanoid; A3LY48; -.
DR OMA; HYCPQVR; -.
DR OrthoDB; 24935at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR005612; CCAAT-binding_factor.
DR InterPro; IPR011501; Noc3_N.
DR InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR PANTHER; PTHR14428; NUCLEOLAR COMPLEX PROTEIN 3; 1.
DR PANTHER; PTHR14428:SF5; NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG; 1.
DR Pfam; PF03914; CBF; 1.
DR Pfam; PF07540; NOC3p; 1.
DR PIRSF; PIRSF028977; Nucleolar_complex_p3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258};
KW Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT DOMAIN 132..222
FT /note="Nucleolar complex-associated protein 3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07540"
FT DOMAIN 504..693
FT /note="CCAAT-binding factor"
FT /evidence="ECO:0000259|Pfam:PF03914"
FT REGION 1..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..90
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 81117 MW; F631021315A5D83E CRC64;
MGKRKNNVKE QEKRKKAKQE KDSLLSTGLF QNNIGEEREN DSNVPNDWDN EEQDYELRPR
KLKNSGKVVE GLPIKTSEGK IERVVREIEP EEEPEPESEP EPEQEVPEED EQQKEEEDED
AHLTPTERLN KIKEEVADLA SKLIEDPEEN ISCLTRLRKM SESHNIVTSQ LAIMALIPVF
KSLAPSYMIR PLTDAEKREK VSREVARLRA YEQSLVSNYT YYIDNLGKMA RVSYSNSANN
SKITPDQLKK GALATKAACE LCLSSLRHFN YRNEVFSIVI RRLNKRPGNP EDLEIFTKSL
RVLETLLKED EENGDITHEV IKLMCKSIRD KKFRVDESVI NVFLSLSLLE DYDPNHNRDD
MPQKKLKKKD RVHLSKKERK ARKERKEIDE EMRRAEQAIT VEQREKYQAE VLKMLLMLYL
EILKAGSHTL ESGRNDATLL MASVLEGLAR FGQMANFDLL GDFLEVLREI MGDIIDEHNL
GNFDANIDDE TGGVYDGKQL RTVLLCIATS FSLMLNHGST GRLPMTIDLS KFVSSLYLIL
ADLSVDTDLE FSHKTLRLAD PLSMEQVAEK PAVNVSTKAE LLLRCLDFIF FRSKNGSVAR
AASFTKRLYL TALQTPEKTS LATLKFIGKL VSRYDESMKG LWNTEERISG EGSYVLGIER
DDREIELERS NSGAATLWEN VLLDKHYCPL VRDGSRTLMN SSKVSNNNR
//
