ID A3PDH2_PROM0 Unreviewed; 490 AA.
AC A3PDH2;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Predicted membrane-associated HD superfamily hydrolase {ECO:0000313|EMBL:ABO17797.1};
GN OrderedLocusNames=P9301_11741 {ECO:0000313|EMBL:ABO17797.1};
OS Prochlorococcus marinus (strain MIT 9301).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=167546 {ECO:0000313|EMBL:ABO17797.1, ECO:0000313|Proteomes:UP000001430};
RN [1] {ECO:0000313|EMBL:ABO17797.1, ECO:0000313|Proteomes:UP000001430}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9301 {ECO:0000313|EMBL:ABO17797.1,
RC ECO:0000313|Proteomes:UP000001430};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
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DR EMBL; CP000576; ABO17797.1; -; Genomic_DNA.
DR RefSeq; WP_011863125.1; NC_009091.1.
DR AlphaFoldDB; A3PDH2; -.
DR STRING; 167546.P9301_11741; -.
DR KEGG; pmg:P9301_11741; -.
DR eggNOG; COG1480; Bacteria.
DR HOGENOM; CLU_015767_3_0_3; -.
DR OrthoDB; 9806952at2; -.
DR Proteomes; UP000001430; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR006675; HDIG_dom.
DR InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR NCBIfam; TIGR00277; HDIG; 1.
DR PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR Pfam; PF07698; 7TM-7TMR_HD; 1.
DR Pfam; PF01966; HD; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ABO17797.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001430};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 273..429
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
SQ SEQUENCE 490 AA; 55133 MW; BFDD32FB4D0366B3 CRC64;
MQNITSTLKK LFYLWKRSQV PVKQPTKISK IDNLIIFLIC ILISITSSYK LLLTSPLNIS
NIFSWILTFT EAFVGSWILI LVSKKENPTL SSRQIILIVT LLLAVQVSKL ALAATISPLS
LIIPPALIIS QGMGSITALV WVSIASISWP EPEVSFNNNL FFILLVCASV VSLLGGRIRS
RAQLLQLSIF VPIGALFSQW IFIGKDKISF IEKQEFVFAN DNIFSDSLLL AIVMLFTILF
IPIFESIFGL LTKARLLELA DKEKPLIRRL SLEAPGTFEH TLLICGLAEE ATRMIGGDID
LIKTGALYHD VGKLHAPSWF IENQDGSKNP HDEIDDPIKS AEVLQAHVDE GLKYARKNRL
PKLIANFIPE HQGTLKMGYF FQKAKEKNLV INENYFRYKG PIPQSKETAI LMLADGCEAA
LRAMNINASD KEALETISKI IFSRQIDGQL DNSNLSKGEI FLIKRSFLNV WKRIRHRRIQ
YPTSKNNTFS
//
