ID A3QRJ8_CAVPO Unreviewed; 905 AA.
AC A3QRJ8;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 122.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|EMBL:ABD77101.1, ECO:0000313|Ensembl:ENSCPOP00000004438.2};
GN Name=TLR3 {ECO:0000313|EMBL:ABD77101.1,
GN ECO:0000313|Ensembl:ENSCPOP00000004438.2};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|EMBL:ABD77101.1};
RN [1] {ECO:0000313|EMBL:ABD77101.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lung {ECO:0000313|EMBL:ABD77101.1};
RX PubMed=19568743; DOI=10.1007/s00251-009-0381-z;
RA Astakhova N.M., Perelygin A.A., Zharkikh A.A., Lear T.L., Coleman S.J.,
RA Macleod J.N., Brinton M.A.;
RT "Characterization of equine and other vertebrate TLR3, TLR7, and TLR8
RT genes.";
RL Immunogenetics 61:529-539(2009).
RN [2] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [3] {ECO:0000313|Ensembl:ENSCPOP00000004438.2}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000004438.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AAKN02035968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02035969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ415679; ABD77101.1; -; mRNA.
DR RefSeq; NP_001166500.1; NM_001173029.1.
DR RefSeq; XP_005003432.1; XM_005003375.2.
DR RefSeq; XP_013007061.1; XM_013151607.1.
DR STRING; 10141.ENSCPOP00000026209; -.
DR Ensembl; ENSCPOT00000004982.3; ENSCPOP00000004438.2; ENSCPOG00000004929.4.
DR Ensembl; ENSCPOT00000034267.1; ENSCPOP00000026209.1; ENSCPOG00000004929.4.
DR Ensembl; ENSCPOT00000037417.1; ENSCPOP00000023057.1; ENSCPOG00000004929.4.
DR GeneID; 100135634; -.
DR KEGG; cpoc:100135634; -.
DR CTD; 7098; -.
DR VEuPathDB; HostDB:ENSCPOG00000004929; -.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000159678; -.
DR HOGENOM; CLU_006000_4_1_1; -.
DR OMA; CKDVAPF; -.
DR OrthoDB; 3428126at2759; -.
DR TreeFam; TF325595; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000004929; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0038187; F:pattern recognition receptor activity; IEA:Ensembl.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:Ensembl.
DR GO; GO:0071360; P:cellular response to exogenous dsRNA; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0090594; P:inflammatory response to wounding; IEA:Ensembl.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007254; P:JNK cascade; IEA:Ensembl.
DR GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0060907; P:positive regulation of macrophage cytokine production; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0034346; P:positive regulation of type III interferon production; IEA:Ensembl.
DR GO; GO:0002730; P:regulation of dendritic cell cytokine production; IEA:Ensembl.
DR GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IEA:Ensembl.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0034343; P:type III interferon production; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 17.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 9.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ABD77101.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..905
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015086364"
FT TRANSMEM 705..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 755..898
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 905 AA; 103677 MW; 1CC9ED7BA7D9A770 CRC64;
MKQPLPYQIY SLLGLLLLCI LCASSNNKCT VTQEVADCSH LKLTQVPDDL PTNITVLNLT
HNQLRRLPPA NFTRYSKLTV LDGGFNSISK LEPELCQNLP LLKILNLQHN ELSHVSDKTF
MFCVNLTELH LMSNSIQKIQ NNPFRNQKNL VKLDLSHNGL SSTKLGTQLQ LENLQELRLS
NNKIHALRSE ELDFLGNSSL QKLELSSNQI KEISPGCFHV IGKLFGLLLN NAQLGPSLTE
KLCLELSNTS IQNLSLSNTQ LYRTSNTTFF GLKQTNLTML DLSHNNLNVI GNDSFVWLPH
LKYLFLEYNN IAHLSSRSFY GLSNVRYLNL KRSFTKQSIS LASLPKIDDL SFQWLKCLEY
LNMDDNNIPG IKSGMFTGLI NLKYLGLSNT FTNLQTLTNE TFLSLAHSPL RVLNLTRNKI
SKLESGAFSC LGDLEVLDLG LNEIEQELTG QEWRGLGNIF EIYLSYNKYL QLTSNSFASV
PGLQRLMLRR VGLKSIDSSP SPFHNLRDLT ILDLSNNNIA NIDEEMLEGL EKLEILDLQH
NNLARLWKHV NPGGPVHFLK GLYHLHILNL ESNGFDEIPA DVFKDLLELK SINLGLNNLN
ILPPSVFDHQ LSLKSLNLQK NLITSVEKNV FEPVFQNLTY LDMRFNPFDC TCESIAWFVN
WINKTHTHIS ELSSHYVCNT PHQSHGFPVM LFDTAPCKDS APFELFFMIS TSVLLIFIFI
VLLIHFEGWR ISFFWNVLVH RVLGFKEVDG QPEQFEYTAY IIHAYKDRDW VWENFSPLEE
KDQSLKFCLE ERDFEAGALE LEAIVNSIKR SRKIVFIITQ HLLKDPLCKR FKVHHAVQQA
IEQNLDSIIL IFLENIPDYK LNHALCLRRG MFRSHCILNW PVQKERTNAF HHKLQVALGS
RNTVY
//
