ID A3THK6_9MICO Unreviewed; 297 AA.
AC A3THK6;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=HxlR family transcriptional regulator {ECO:0008006|Google:ProtNLM};
GN ORFNames=JNB_09094 {ECO:0000313|EMBL:EAQ00316.1};
OS Janibacter sp. HTCC2649.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Janibacter.
OX NCBI_TaxID=313589 {ECO:0000313|EMBL:EAQ00316.1, ECO:0000313|Proteomes:UP000005063};
RN [1] {ECO:0000313|EMBL:EAQ00316.1, ECO:0000313|Proteomes:UP000005063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2649 {ECO:0000313|EMBL:EAQ00316.1,
RC ECO:0000313|Proteomes:UP000005063};
RX PubMed=21075932; DOI=10.1128/JB.01298-10;
RA Thrash J.C., Cho J.C., Bertagnolli A.D., Ferriera S., Johnson J.,
RA Vergin K.L., Giovannoni S.J.;
RT "Genome sequence of the Marine Janibacter Sp. Strain HTCC2649.";
RL J. Bacteriol. 193:584-585(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ00316.1}.
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DR EMBL; AAMN01000001; EAQ00316.1; -; Genomic_DNA.
DR RefSeq; WP_009776122.1; NZ_CH672413.1.
DR AlphaFoldDB; A3THK6; -.
DR STRING; 313589.JNB_09094; -.
DR eggNOG; COG1225; Bacteria.
DR eggNOG; COG1733; Bacteria.
DR HOGENOM; CLU_993619_0_0_11; -.
DR OrthoDB; 9792527at2; -.
DR Proteomes; UP000005063; Unassembled WGS sequence.
DR GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd03017; PRX_BCP; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR002577; HTH_HxlR.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33204; TRANSCRIPTIONAL REGULATOR, MARR FAMILY; 1.
DR PANTHER; PTHR33204:SF26; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR Pfam; PF01638; HxlR; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51118; HTH_HXLR; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005063};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..108
FT /note="HTH hxlR-type"
FT /evidence="ECO:0000259|PROSITE:PS51118"
FT DOMAIN 126..291
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 297 AA; 31088 MW; D04EC97C6552B21E CRC64;
MRREDLADED CGIAQSLGVL GDWWTFLIVR DVAGGVTRFD ALQRELGISR RALTERLAGL
VADGVLDKRA YSERPPRHDY VLTPKGEGLL PVLVALQDWG ARHVLGDGSV SAGITADSAE
SRRVGDLVGH ALPPITLTGH DGIRVALSSG SWTVLFCMPG AWAPAAQGYS PGWGEIPGAA
GCTVEAMAYA AQHDAFAARG VVVHGVSTQR PDQQAAFAEH ASLPYVLLSD EDVSLAGALR
LPTFRAGGVD RLKRVTLVVD PAGVVRAVQA PVTDPAGSAL EMLGVLDELM AGVATSA
//
