ID A3TRV3_9MICO Unreviewed; 228 AA.
AC A3TRV3;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 13-SEP-2023, entry version 61.
DE RecName: Full=Putative pterin-4-alpha-carbinolamine dehydratase {ECO:0000256|ARBA:ARBA00021735};
DE EC=4.2.1.96 {ECO:0000256|ARBA:ARBA00013252};
GN ORFNames=JNB_20198 {ECO:0000313|EMBL:EAP96968.1};
OS Janibacter sp. HTCC2649.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Intrasporangiaceae;
OC Janibacter.
OX NCBI_TaxID=313589 {ECO:0000313|EMBL:EAP96968.1, ECO:0000313|Proteomes:UP000005063};
RN [1] {ECO:0000313|EMBL:EAP96968.1, ECO:0000313|Proteomes:UP000005063}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2649 {ECO:0000313|EMBL:EAP96968.1,
RC ECO:0000313|Proteomes:UP000005063};
RX PubMed=21075932; DOI=10.1128/JB.01298-10;
RA Thrash J.C., Cho J.C., Bertagnolli A.D., Ferriera S., Johnson J.,
RA Vergin K.L., Giovannoni S.J.;
RT "Genome sequence of the Marine Janibacter Sp. Strain HTCC2649.";
RL J. Bacteriol. 193:584-585(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin =
CC (6R)-L-erythro-6,7-dihydrobiopterin + H2O; Xref=Rhea:RHEA:11920,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15642, ChEBI:CHEBI:43120; EC=4.2.1.96;
CC Evidence={ECO:0000256|ARBA:ARBA00001554};
CC -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine dehydratase
CC family. {ECO:0000256|ARBA:ARBA00006472}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAP96968.1}.
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DR EMBL; AAMN01000006; EAP96968.1; -; Genomic_DNA.
DR RefSeq; WP_009778315.1; NZ_CH672413.1.
DR AlphaFoldDB; A3TRV3; -.
DR STRING; 313589.JNB_20198; -.
DR eggNOG; COG2154; Bacteria.
DR HOGENOM; CLU_109854_0_0_11; -.
DR OrthoDB; 15077at2; -.
DR Proteomes; UP000005063; Unassembled WGS sequence.
DR GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 1.
DR Gene3D; 3.30.1360.20; Transcriptional coactivator/pterin dehydratase; 1.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR041581; Glyoxalase_6.
DR InterPro; IPR036428; PCD_sf.
DR InterPro; IPR001533; Pterin_deHydtase.
DR Pfam; PF18029; Glyoxalase_6; 1.
DR Pfam; PF01329; Pterin_4a; 1.
DR SUPFAM; SSF55248; PCD-like; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000005063}.
FT DOMAIN 120..221
FT /note="Glyoxalase-like"
FT /evidence="ECO:0000259|Pfam:PF18029"
SQ SEQUENCE 228 AA; 24249 MW; 46E34571631EBF15 CRC64;
MDMLRGEQIA EATLTDWRKL AQGLHARYLV DDFGTAARFV AAVGEAGDAV GHHPRVSIGE
GYVDLRLVTH DAIYRDDDGT EYVVEWPTQQ DVDLARRITE VAAEHTLTAD PAAVSVIELG
LDTAESATIA PVWAALLTGD AEAQGRGTPG DEIRDATGRT PNLWFGDSVE QDSPQRFHVE
VYVAAEVAEQ RIAAAVAAGG TIVDDSQSPS LTVIADQDGN RGVLCVAG
//
