ID A3U974_CROAH Unreviewed; 773 AA.
AC A3U974;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=CA2559_10008 {ECO:0000313|EMBL:EAP86360.1};
OS Croceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Croceibacter.
OX NCBI_TaxID=216432 {ECO:0000313|EMBL:EAP86360.1, ECO:0000313|Proteomes:UP000002297};
RN [1] {ECO:0000313|EMBL:EAP86360.1, ECO:0000313|Proteomes:UP000002297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-628 / HTCC2559 / KCTC 12090
RC {ECO:0000313|Proteomes:UP000002297};
RX PubMed=20639333; DOI=10.1128/JB.00733-10;
RA Oh H.M., Kang I., Ferriera S., Giovannoni S.J., Cho J.C.;
RT "The complete genome sequence of Croceibacter atlanticus HTCC2559T.";
RL J. Bacteriol. 192:4796-4797(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP002046; EAP86360.1; -; Genomic_DNA.
DR RefSeq; WP_013187745.1; NC_014230.1.
DR AlphaFoldDB; A3U974; -.
DR STRING; 216432.CA2559_10008; -.
DR KEGG; cat:CA2559_10008; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_004585_5_2_10; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000002297; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000002297}.
FT DOMAIN 6..291
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 292..573
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 678..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 27..34
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 773 AA; 88680 MW; 16420D806689D12D CRC64;
MIDYLKGLND AQRAPVLQKD GAMIVIAGAG SGKTRVLTMR IAHLMKNGVD PFNILSLTFT
NKAAKEMKKR ISEIVGASEA KNLWMGTFHS IFAKILRFEA DKLGYPSNFT IYDTQDSQSL
IRAIIKEMHL DKDVYKYKQV YSRISSYKNS LITVKAYFQN PELIEADAMA KRPRLGDIYK
EYVERCFKAG AMDFDDLLLR TNELLNRFPE VLNKYQNRFK YILVDEYQDT NHSQYLIVRA
LSDKFQNICV VGDDAQSIYA FRGANINNIL NFQRDYDNVE MYRLEQNYRS TKNIVNAANS
IIDKNKTKLD KVVWTANDEG PKIRVNRLIN DGEEGRFVAS SIFENKMEHQ LRNGQFAILY
RTNAQSRAME DALRKKDIPY RIYGGLSFYQ RKEIKDVISY LRLIANPNDE EALKRVINYP
TRGIGQTTID KVAIAANHYK RSMFEVMANI DKVDIGVNTG TKNKLKNFVN MIHHFQILNK
ESDAFSVAEA VAKKTGLIQD LKKDGTPEGV ARIENVEELL NGIKDFVEGQ VELADATGSL
AEFLEDIALA TDMDKEVGDD DRVALMTIHL AKGLEFPYVY IVGMEEDLFP SAMSMNTRSE
LEEERRLFYV ALTRAEKQAY LTYTQSRYRW GKLIDAEPSR FIEEIDEQYI DWMIPQDDYK
YKPLVSPDLW GDVDKSKFRQ TKPKKGTPPP SHKPTDEQLR KLRRLRPTDA SKEVQKAAPI
SLSEGQMVEH MRFGKGKVIK IEGVGQDKKA EIDFENGGLK KLLLRFAKLK MLD
//
