ID A3UAV4_CROAH Unreviewed; 543 AA.
AC A3UAV4;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00012884};
DE EC=1.2.1.88 {ECO:0000256|ARBA:ARBA00012884};
DE AltName: Full=L-glutamate gamma-semialdehyde dehydrogenase {ECO:0000256|ARBA:ARBA00032259};
GN OrderedLocusNames=CA2559_12908 {ECO:0000313|EMBL:EAP86940.1};
OS Croceibacter atlanticus (strain ATCC BAA-628 / HTCC2559 / KCTC 12090).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Croceibacter.
OX NCBI_TaxID=216432 {ECO:0000313|EMBL:EAP86940.1, ECO:0000313|Proteomes:UP000002297};
RN [1] {ECO:0000313|EMBL:EAP86940.1, ECO:0000313|Proteomes:UP000002297}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-628 / HTCC2559 / KCTC 12090
RC {ECO:0000313|Proteomes:UP000002297};
RX PubMed=20639333; DOI=10.1128/JB.00733-10;
RA Oh H.M., Kang I., Ferriera S., Giovannoni S.J., Cho J.C.;
RT "The complete genome sequence of Croceibacter atlanticus HTCC2559T.";
RL J. Bacteriol. 192:4796-4797(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-
CC glutamate + NADH; Xref=Rhea:RHEA:30235, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945, ChEBI:CHEBI:58066; EC=1.2.1.88;
CC Evidence={ECO:0000256|ARBA:ARBA00001468};
CC -!- PATHWAY: Amino-acid degradation; L-proline degradation into L-
CC glutamate; L-glutamate from L-proline: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004786}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009986}.
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DR EMBL; CP002046; EAP86940.1; -; Genomic_DNA.
DR RefSeq; WP_013188321.1; NC_014230.1.
DR AlphaFoldDB; A3UAV4; -.
DR STRING; 216432.CA2559_12908; -.
DR KEGG; cat:CA2559_12908; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_4_1_10; -.
DR OrthoDB; 973733at2; -.
DR UniPathway; UPA00261; UER00374.
DR Proteomes; UP000002297; Chromosome.
DR GO; GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway.
DR CDD; cd07123; ALDH_F4-17_P5CDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR005931; P5CDH/ALDH4A1.
DR NCBIfam; TIGR01236; D1pyr5carbox1; 1.
DR PANTHER; PTHR42862; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR42862:SF1; DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Proline metabolism {ECO:0000256|ARBA:ARBA00023062};
KW Reference proteome {ECO:0000313|Proteomes:UP000002297}.
FT DOMAIN 60..512
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 543 AA; 60188 MW; 005EB471EEF26CF5 CRC64;
MGKGFFHVPP AVNEPIKSYA PGSPEREEVL NTYKELYNST VEVPCYINGK EVKTGDTATM
HPPHDHKHTL GTYHKATREN VEEAIEGSLK ARQEWADLPW EQRAAVFLRA AELIAGPYRA
KINAATMLAQ SKTIFQAEID SACELIDFLR FNVEYMTQIF DDQPESTSEA WNRVEYRPLE
GFVYAITPFN FTAIAGNLPA SAALMGNVAL WKPSDSQVYS AQVVMEVFKE AGVPDGVINM
VMGDPVMISD VAISHPDFTG LHFTGSTNVF QDLWKTIGNN IHTYKTYPRI VGETGGKDFI
MAHKSADAKQ VATAIARGAF EFQGQKCSAC SRCYIPKSLW ADVKKYLVED VKSFKMGSPE
DMGNFVTAVI HEGSFDKLAS YIDKAKEDKD AEIIVGGNYD KSKGWFVEPT VIVTDNPKYT
TMQTELFGPV VTIYVYEDEE FDDTLKLVDE TSIYALTGSI FSTDRHAAAH ATKALQNCAG
NFYINDKCTG AVVGQQPFGG ARASGTNDKA GSKLNLLRWV SPRLIKETFV APKDYRYPFL
GED
//
