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Database: UniProt
Entry: A3WAA6_9SPHN
LinkDB: A3WAA6_9SPHN
Original site: A3WAA6_9SPHN 
ID   A3WAA6_9SPHN            Unreviewed;       436 AA.
AC   A3WAA6;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   08-MAY-2019, entry version 55.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=NAP1_00385 {ECO:0000313|EMBL:EAQ29183.1};
OS   Erythrobacter sp. NAP1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter.
OX   NCBI_TaxID=237727 {ECO:0000313|EMBL:EAQ29183.1, ECO:0000313|Proteomes:UP000002995};
RN   [1] {ECO:0000313|EMBL:EAQ29183.1, ECO:0000313|Proteomes:UP000002995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAP1 {ECO:0000313|EMBL:EAQ29183.1,
RC   ECO:0000313|Proteomes:UP000002995};
RX   PubMed=21952547; DOI=10.1128/JB.05845-11;
RA   Koblizek M., Janouskovec J., Obornik M., Johnson J.H., Ferriera S.,
RA   Falkowski P.G.;
RT   "Genome Sequence of the Marine Photoheterotrophic Bacterium
RT   Erythrobacter sp. Strain NAP1.";
RL   J. Bacteriol. 193:5881-5882(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAQ29183.1}.
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DR   EMBL; AAMW01000001; EAQ29183.1; -; Genomic_DNA.
DR   RefSeq; WP_007163214.1; NZ_CH672390.1.
DR   STRING; 237727.NAP1_00385; -.
DR   EnsemblBacteria; EAQ29183; EAQ29183; NAP1_00385.
DR   eggNOG; ENOG4105C6Y; Bacteria.
DR   eggNOG; COG1004; LUCA.
DR   OrthoDB; 647136at2; -.
DR   Proteomes; UP000002995; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002995};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002995}.
FT   DOMAIN      319    420       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    263    263       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     122    122       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     155    155       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     266    266       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     333    333       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   436 AA;  46909 MW;  4A9E43D4D70F876A CRC64;
     MKIAMVGSGY VGLVSGACFA DFGHDVVCID KDQGKIDRLH DGIMPIYEPG LDALVESNVK
     AGRLSFTTSL AEGIKDAAAV FIAVGTPSRR GDGHADLSFV YAVAKEVGES LANDAVVVTK
     STVPVGTGDE VERLLKESGT PHRVSVVSNP EFLREGAAIG DFKRPDRIVI GAEDDFGREV
     MREVYRPLFL NESPILFTSR RTSELIKYAA NAFLATKITF INEMADLCEK VGANVQDVSR
     GIGMDNRIGA KFLHAGPGYG GSCFPKDTLA LLKTAEDYDS PTRIIEAVVK VNDSRKRAMG
     RKVLDSIGGP ENARGKKVAL LGLTFKPNTD DMRDSPAIAV AQTLTDAGVK VSAFDPEGME
     QARPLMPAVN MCDDPYAAIE DADATVIVTE WDAFRALDLS RVKDLAKAPV LVDLRNIYNP
     DDVRNAGFTY ASIGRD
//
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