ID A3XKX5_LEEBM Unreviewed; 613 AA.
AC A3XKX5;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Endo-1,4-beta-xylanase D {ECO:0000313|EMBL:EAQ49797.1};
GN ORFNames=MED217_01565 {ECO:0000313|EMBL:EAQ49797.1};
OS Leeuwenhoekiella blandensis (strain CECT 7118 / CCUG 51940 / KCTC 22103 /
OS MED217) (Flavobacterium sp. (strain MED217)).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Leeuwenhoekiella.
OX NCBI_TaxID=398720 {ECO:0000313|EMBL:EAQ49797.1, ECO:0000313|Proteomes:UP000001601};
RN [1] {ECO:0000313|EMBL:EAQ49797.1, ECO:0000313|Proteomes:UP000001601}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MED217 {ECO:0000313|EMBL:EAQ49797.1,
RC ECO:0000313|Proteomes:UP000001601};
RX PubMed=17215843; DOI=10.1038/nature05381;
RA Gomez-Consarnau L., Gonzalez J.M., Coll-Llado M., Gourdon P., Pascher T.,
RA Neutze R., Pedros-Alio C., Pinhassi J.;
RT "Light stimulates growth of proteorhodopsin-containing marine
RT Flavobacteria.";
RL Nature 445:210-213(2007).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ49797.1}.
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DR EMBL; AANC01000003; EAQ49797.1; -; Genomic_DNA.
DR AlphaFoldDB; A3XKX5; -.
DR STRING; 398720.MED217_01565; -.
DR eggNOG; COG3507; Bacteria.
DR HOGENOM; CLU_010779_2_0_10; -.
DR Proteomes; UP000001601; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0045493; P:xylan catabolic process; IEA:UniProtKB-KW.
DR CDD; cd08983; GH43_Bt3655-like; 1.
DR CDD; cd18618; GH43_Xsa43E-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 2.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 2.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000313|EMBL:EAQ49797.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAQ49797.1};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651,
KW ECO:0000313|EMBL:EAQ49797.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001601};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651,
KW ECO:0000313|EMBL:EAQ49797.1}.
FT ACT_SITE 335
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 504
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 456
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 613 AA; 69940 MW; 81CDE862D017C75E CRC64;
MQGYLFAYFE GTGADQEAIR FAVSDDAVHW KALNQNNPII PSAAISNTGG VRDPHLLRGA
EADGFYMVAT DMFTKKDGWD TNPGIVLMHS DDLITWQSTA INLEKSYPKF KNTKWVWAPQ
TFYDTKKKKY LVYFTVRSHD NLKLDFYAAY ANKDFTGFEA EPKLLYSAKD GAIDGDIIYK
DGTYHLFYKG NTKDAAGKEI QNGIKQATSE KLLGPYTESF DYIDFYADKK TTVEGSSVFK
LNDKDEYILM YDLYSSGRYE FQRSKDLYTF TKETESFTKD FHPRHGSVIS ITKEEAQRLD
QKWDGVPVSL LTDAQGRYRF QSQGNPIIQH KYTADPAALV ENDTLWLFTG HDYAGGQKGY
KMKDWLVYST TDLKNWTEHP VPLKIDDFTW ATSGDAYAGH VAKRNGKYYW YISTNWNGIG
VAVADKPEGP YKDALGKPLL TNEDCFASSH SWTCIDPAIF IDKDDQPWIF WGNGVCYYAK
LKDNMIEIEG EIKTIDFEGL EFTEAPWVHE RDGKYYLTYA TEFPEKIAYA VADKIDGPYT
YKGILNEIAG NSNTNHQSIV EFKNDWYFIY HNGGIQPDGS SYSRSVCIDP LHYNEDGSLE
RIQMTTEGVQ AKN
//
