ID A3YXA4_9SYNE Unreviewed; 396 AA.
AC A3YXA4;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369};
GN ORFNames=WH5701_00930 {ECO:0000313|EMBL:EAQ75368.1};
OS Synechococcus sp. WH 5701.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=69042 {ECO:0000313|EMBL:EAQ75368.1, ECO:0000313|Proteomes:UP000002935};
RN [1] {ECO:0000313|EMBL:EAQ75368.1, ECO:0000313|Proteomes:UP000002935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH5701 {ECO:0000313|Proteomes:UP000002935};
RA Scanlan D., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC {ECO:0000256|ARBA:ARBA00005163}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAQ75368.1}.
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DR EMBL; AANO01000004; EAQ75368.1; -; Genomic_DNA.
DR AlphaFoldDB; A3YXA4; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_2_1_3; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; -.
DR Proteomes; UP000002935; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0036440; F:citrate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR011278; 2-MeCitrate/Citrate_synth_II.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR NCBIfam; TIGR01800; cit_synth_II; 1.
DR PANTHER; PTHR11739; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR11739:SF4; CITRATE SYNTHASE, PEROXISOMAL; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EAQ75368.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002935};
KW Transferase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000313|EMBL:EAQ75368.1}.
FT ACT_SITE 273
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 327
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 396 AA; 44057 MW; 9A5B5195978ADF2C CRC64;
MRMVVDANRV AAEAAPVFRP GLEGVPATQS AICDIDGLQG LLTYRGYPLE ELAAYSTFLE
TAHLLIWGEL PTVEHLRAFE HNVQMHRRVS FRIRDMMKCF PADGHPMDAL QSSAASLGLF
YSRRALDDPA YIEAAVVRLI AKIPTMVAAY QLIRLGQDPI QPRDDLSYSA NFLYMLTERE
PDPLAARIFD ACLILHAEHS LNASTFSARV TASTLTDPYA VVASAVGTLA GPLHGGANED
VLAMLEQIGS EDQAEAWLDR AIAEKQKIMG FGHREYKVKD PRAVILQGLA EQLFDRFGHD
AMYDVARRVE EVASDRLGPK GIYPNVDFYS GLVYRKLGIP RDLFTPIFAI ARVAGWLAHW
KEQLGANRIY RPTQIYTGYG RRSWLPQDAR NALPGV
//
