ID   A4AFX0_9ACTN            Unreviewed;       327 AA.
AC   A4AFX0;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=Acetoin dehydrogenase (TPP-dependent) alpha chain {ECO:0000313|EMBL:EAR25876.1};
GN   ORFNames=A20C1_08348 {ECO:0000313|EMBL:EAR25876.1};
OS   marine actinobacterium PHSC20C1.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=312284 {ECO:0000313|EMBL:EAR25876.1, ECO:0000313|Proteomes:UP000003868};
RN   [1] {ECO:0000313|EMBL:EAR25876.1, ECO:0000313|Proteomes:UP000003868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHSC20C1 {ECO:0000313|EMBL:EAR25876.1,
RC   ECO:0000313|Proteomes:UP000003868};
RA   Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA   Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAR25876.1}.
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DR   EMBL; AAOB01000002; EAR25876.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4AFX0; -.
DR   STRING; 312284.A20C1_08348; -.
DR   eggNOG; COG1071; Bacteria.
DR   HOGENOM; CLU_029393_5_0_11; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000003868; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003868}.
FT   DOMAIN          25..313
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   327 AA;  34563 MW;  FDD5E109ADDE9916 CRC64;
     MTYHPVNPTL ADPLPADALE LLRSMYEIRF FEDEIMGLFS QNLVRGSTHL CQGQEAVTVG
     VCSALSPGDT MTCTYRGHGA VLAMGAPLDR AFGEILGRAG GLCGGKGGSM HLADVSVGAL
     GSNAIVGGHL PTTVGAALAA SYRGTSEVSV AFFGDGSTNI GAFHESLNLA SIWKLPAIFV
     IENNQYGEYS TLASTTPIER LSDRAASYGM PGVFVDGNDV IAMRSATKTA VERARAGEGP
     TLIEADTYRH SGHSRSDPAK YRPEEEVKSW FARDPIVQLR NAIEASGGAD AAAEVERTAH
     TDVDAARDLA LTWPEPELSA GMEHIYS
//