ID A4AJB9_9ACTN Unreviewed; 430 AA.
AC A4AJB9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=histidine--tRNA ligase {ECO:0000256|ARBA:ARBA00012815};
DE EC=6.1.1.21 {ECO:0000256|ARBA:ARBA00012815};
DE AltName: Full=Histidyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030619};
GN ORFNames=A20C1_12712 {ECO:0000313|EMBL:EAR24492.1};
OS marine actinobacterium PHSC20C1.
OC Bacteria; Actinomycetota; Actinomycetes.
OX NCBI_TaxID=312284 {ECO:0000313|EMBL:EAR24492.1, ECO:0000313|Proteomes:UP000003868};
RN [1] {ECO:0000313|EMBL:EAR24492.1, ECO:0000313|Proteomes:UP000003868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHSC20C1 {ECO:0000313|EMBL:EAR24492.1,
RC ECO:0000313|Proteomes:UP000003868};
RA Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001137};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAR24492.1}.
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DR EMBL; AAOB01000007; EAR24492.1; -; Genomic_DNA.
DR AlphaFoldDB; A4AJB9; -.
DR STRING; 312284.A20C1_12712; -.
DR eggNOG; COG0124; Bacteria.
DR HOGENOM; CLU_025113_3_0_11; -.
DR OrthoDB; 9800814at2; -.
DR Proteomes; UP000003868; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00773; HisRS-like_core; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR NCBIfam; TIGR00442; hisS; 1.
DR PANTHER; PTHR11476:SF7; HISTIDINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11476; HISTIDYL-TRNA SYNTHETASE; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:EAR24492.1};
KW Ligase {ECO:0000313|EMBL:EAR24492.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003868}.
FT DOMAIN 22..395
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 430 AA; 46754 MW; FA98252B0E31EEAF CRC64;
MASTVNPPRG MRDFLPAEKA RRERVLGVIR GSYRAHGFDE IETPVMEDSS RLHAGLGGDN
EKLAFAVMKR GLTADKLQAA SEALDLADLG LRFDLTVPLA RFYATHRAEL PKVFRAIQIA
PVWRAERPQK GRYRQFVQCD IDIMGEAGPS AEIELITATA ATLDALGIDG CTIRVNDRRL
LSSALTILGF PLKEHDAVLI TVDKLDKLGA EGVIAELRER AFPNAPVAAL AEFLSRPQPE
IKTEFTADAI RAALPAGVNE TVISELAAIG HAVEAGRGTS GALIEFDPWL VRGMGYYTGA
IFEVAHPSLG YSLGGGGRYD GMIGRFLGSD VPAVGFSLGF ERLVDLVELD EASEDDQLAL
IYDADVNPTV LVRLQAELIR SGKRVRLESR PRKLPQLLDQ LRDAGFTSFA IVRTDAGDVA
SLDFKVFDEQ
//
