ID   A4ALS1_9ACTN            Unreviewed;       517 AA.
AC   A4ALS1;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=DNA polymerase A {ECO:0000313|EMBL:EAR23672.1};
GN   ORFNames=A20C1_03268 {ECO:0000313|EMBL:EAR23672.1};
OS   marine actinobacterium PHSC20C1.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=312284 {ECO:0000313|EMBL:EAR23672.1, ECO:0000313|Proteomes:UP000003868};
RN   [1] {ECO:0000313|EMBL:EAR23672.1, ECO:0000313|Proteomes:UP000003868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHSC20C1 {ECO:0000313|EMBL:EAR23672.1,
RC   ECO:0000313|Proteomes:UP000003868};
RA   Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA   Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC       {ECO:0000256|ARBA:ARBA00007705}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAR23672.1}.
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DR   EMBL; AAOB01000017; EAR23672.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4ALS1; -.
DR   STRING; 312284.A20C1_03268; -.
DR   eggNOG; COG0749; Bacteria.
DR   HOGENOM; CLU_526577_0_0_11; -.
DR   OrthoDB; 5196455at2; -.
DR   Proteomes; UP000003868; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.370; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR002298; DNA_polymerase_A.
DR   PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR   PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR   Pfam; PF00476; DNA_pol_A; 1.
DR   PRINTS; PR00868; DNAPOLI.
DR   SMART; SM00482; POLAc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003868}.
FT   DOMAIN          293..483
FT                   /note="DNA-directed DNA polymerase family A palm"
FT                   /evidence="ECO:0000259|SMART:SM00482"
SQ   SEQUENCE   517 AA;  56165 MW;  69DD797F5E659ED9 CRC64;
     MTLVTAATLP TFDKWLVEKR PLGIALNAPG TVLGVADLKT AWTVDIADEF LVRAVASKIQ
     DRQRRAWAMS PEVVHTLARV TEYDLEDFSW INDVAVAFHS AHPGVELPLM APGAGPRARQ
     AASLMKALAL QVPAAGHLMM NLTVALDQAF RESQRRGVRV DVEGLREAQD LNRSVTAAAT
     AEDGIDLSAV GTDAQAEAVT GWLAGRDITI RDFDGRPSLS RDFFDRAQIP DSSEGRYFWG
     RFRAAASRRS ARLSLNQIAN NLHDDGHVFP MVHLRGAKTG RGSVTGPALT SLSKKYRSLI
     IPEDGAVFIS LDFDRAEPTV AAALSQDEGL QEALSTTDVY RELAVKVFGE QAREDDIARA
     TCKTIFLGIL YGRGAQGLSQ QLGISKAEAT ETIRSVWDSF PALNAYCEGL KADAIAGKEL
     RTPWGRLLPV PNRGPYQTPN LMIQASAADV FYVGLKNVVE LLGADRLTLP IHDEILLQSS
     QGDVFRSSAL LEEAMTVPFL NMTVTGQTKQ LGGSWSR
//